Protein Info for UW163_RS22515 in Ralstonia solanacearum UW163

Annotation: type I secretion system permease/ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 724 transmembrane" amino acids 171 to 192 (22 residues), see Phobius details amino acids 205 to 227 (23 residues), see Phobius details amino acids 278 to 302 (25 residues), see Phobius details amino acids 307 to 329 (23 residues), see Phobius details amino acids 374 to 392 (19 residues), see Phobius details amino acids 397 to 415 (19 residues), see Phobius details PF03412: Peptidase_C39" amino acids 22 to 143 (122 residues), 67.9 bits, see alignment E=1.3e-22 TIGR01846: type I secretion system ATPase" amino acids 25 to 720 (696 residues), 1009.5 bits, see alignment E=3.8e-308 PF00664: ABC_membrane" amino acids 171 to 437 (267 residues), 202.7 bits, see alignment E=1.5e-63 PF00005: ABC_tran" amino acids 500 to 648 (149 residues), 117.6 bits, see alignment E=1e-37

Best Hits

Swiss-Prot: 66% identical to CYAB_BORP1: Cyclolysin secretion/processing ATP-binding protein CyaB (cyaB) from Bordetella pertussis (strain ATCC 9797 / DSM 5571 / NCTC 10739 / 18323)

KEGG orthology group: K11004, ATP-binding cassette, subfamily B, bacterial HlyB/CyaB (inferred from 97% identity to rsl:RPSI07_mp0280)

Predicted SEED Role

"cyclolysin secretion ATP-binding protein" in subsystem cAMP signaling in bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (724 amino acids)

>UW163_RS22515 type I secretion system permease/ATPase (Ralstonia solanacearum UW163)
MTSTTIDTPATPGPEPTRADIDTALACLLMMARLHGIAAEEAQLRHEFGHRAFDTQTALL
AAKHLGLSAKAVRQPVERLDRAPLPAIAIDQSGQHFILAKYDATNADEPKLLIQRPGHPP
SVLTLQDFLAAWSGELILCTSKATFAGDMAKFDFTWFIPAVVKYRKLLGEVLLVSLTLQI
IGLVTPMFFQVVMDKVLVNHAMKTLNVIAVGLICAILFEVTLTSIRTWVFAHTSSKIDVE
LGARLFRHLLSLPLAYFQSRRVGDSVARVRELENIRSFLTGNAMTVVLDLMFSFVFLAVM
LWYSVWLTLIVVVSIPLYIGLSALFTPVIRARLDVKFNRNAENQSFLVETISGIDTVKAM
AVEPRWTHKWDQQLAAYVTAGLAVTNVATIASGGVTLVSKLVTAAIMWLGATLVIDHKMT
VGELVAFNMLAGQVSSPILRLAQLWNDFQQVGISMSRLGDILNARTEVAGQKSRLPKLAG
AIGFDQVAFRYRPDAPDVIRGISLAIAPGEVIGIVGRSGSGKSTLTKLVQRLYVPERGRV
LIDGQDIAIVDTTSLRQQIGVVLQENTLFNRSIRDNIALTNPAAPLEAIIEAARLAGAHE
FICELPEGYDTIVGEHGTGLSGGQRQRIAIARALLTNPRILIFDEATSALDYESEKIIQD
NMRRICQGRTVLIIAHRLSAVREANRIIVMERGQIAEIGSHDQLLKNPQGIYAHLYALQQ
GGAA