Protein Info for UW163_RS19770 in Ralstonia solanacearum UW163

Annotation: polyketide synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF21089: PKS_DH_N
  • amino acids 57 to 127 (71 residues), 31.3 bits, see alignment (E = 8.2e-11)
  • amino acids 2266 to 2369 (104 residues), 76.3 bits, see alignment (E = 8.4e-25)
• PF14765: PS-DH
  • amino acids 185 to 312 (128 residues), 62.1 bits, see alignment (E = 2.4e-20)
  • amino acids 2394 to 2558 (165 residues), 59.1 bits, see alignment (E = 2.1e-19)
• PF00550: PP-binding
  • amino acids 355 to 400 (46 residues), 34.6 bits, see alignment (E = 9.5e-12)
  • amino acids 1548 to 1612 (65 residues), 47.7 bits, see alignment (E = 7.6e-16)
  • amino acids 3033 to 3095 (63 residues), 41.8 bits, see alignment (E = 5.3e-14)
  • amino acids 4124 to 4189 (66 residues), 51.8 bits, see alignment (E = 3.9e-17)
• PF00109: ketoacyl-synt
  • amino acids 449 to 695 (247 residues), 266.1 bits, 1.7e-82
  • amino acids 1653 to 1892 (240 residues), 257.8 bits, 6e-80
  • amino acids 3170 to 3419 (250 residues), 217.8 bits, 1e-67
• PF02801: Ketoacyl-synt_C
  • amino acids 703 to 820 (118 residues), 127.8 bits, see alignment (E = 1.1e-40)
  • amino acids 1901 to 2017 (117 residues), 121.7 bits, see alignment (E = 8.6e-39)
  • amino acids 3427 to 3543 (117 residues), 122.5 bits, see alignment (E = 4.7e-39)
• PF16197: KAsynt_C_assoc
  • amino acids 824 to 933 (110 residues), 59.7 bits, see alignment (E = 1.8e-19)
  • amino acids 2020 to 2108 (89 residues), 37.4 bits, see alignment (E = 1.6e-12)
• PF08659: KR
  • amino acids 1264 to 1448 (185 residues), 116.9 bits, see alignment (E = 5.2e-37)
  • amino acids 2755 to 2939 (185 residues), 161.3 bits, see alignment (E = 1.2e-50)
• PF00106: adh_short
  • amino acids 2758 to 2914 (157 residues), 41.3 bits, see alignment (E = 6.2e-14)
• PF13561: adh_short_C2
  • amino acids 2794 to 2877 (84 residues), 27.1 bits, see alignment (E = 1.6e-09)

Predicted SEED Role

"Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)" in subsystem Fatty Acid Biosynthesis FASII or mycolic acid synthesis (EC 2.3.1.39)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (50/53 steps found)
• superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (14/16 steps found)
• fatty acid biosynthesis initiation (type II) (3/3 steps found)
• superpathway of fatty acid biosynthesis initiation (4/5 steps found)
• fatty acid biosynthesis initiation (mitochondria) (2/4 steps found)
• fatty acid biosynthesis initiation (plant mitochondria) (1/4 steps found)
• mycobactin biosynthesis (3/11 steps found)
• pederin biosynthesis (2/14 steps found)
• bryostatin biosynthesis (2/19 steps found)
• mupirocin biosynthesis (1/26 steps found)
• corallopyronin A biosynthesis (2/30 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.39

Use Curated BLAST to search for 2.3.1.39

Protein Sequence (4196 amino acids)

>UW163_RS19770 polyketide synthase (Ralstonia solanacearum UW163)
MESPIRVLYRKIQNEEISVEAAAREFETIRASHRREHAERAIQAPPATENPIAAAVYQHD
EPYLRDHQFNHRRILLGLTYASLALESGLGQLADGEALQLKRLTFAAPVALAEGERVEVA
IRAAHQEGPAFEAVCRHAASAPWRPVASGELSAVAARQLQVDPAGLRTGMTAVEPLASIY
RISGQIHIGDSFRTLESLYWRQDGGEALSRVALTALDAADARRYSLHPLLINSAFLTVIP
LLAKAALDGDFIPFGIQSLILHRRQVTPTGWIHAKLVKNSGELVLFDATLYGDDGVLVAE
FNGCSLKRVRGSQLEGGESAGEGEPLSGSEGIESYLLAQLHALGADHIGKKQRRRNLMDL
GLESMQLVRLAGRIASAAAIELEPTVFFEYPSVAELAAFLWQAHRAAFAPLLAQRSASTN
AAPAAASPVVPGLAASRPDSAFASAGGDRDIAIIGMQGRFGEAGDLDQFWRNIWQGRELI
KEVPADHWDVAPWFDADPEAHDRTYSKWGSFIDGVDRFDADFFNMSRREAQWMDPQVRLL
LQSAYASAEHAGVIKRLRGSRTGVFIGSCFNEYLDKITELGLPMDPYIATGSGTIAANRI
SFWFDFKGPSLMFNTACSSSLVALHAACVALRNGECEMAFVGGSNLLLSSWHYRYFSAIR
ALSPTGRCHTFDARADGYVPGECVATLLLKPLSKALADGDPIHGVIKGSAALHGGYTPSL
TAPSVAGEENVIVHAWQDAGIDPRSLSYIEAHGTGTRLGDPIEVNALKRAFARYTGDRGF
CHIGSVKANLGHAEGAAGIAGVLKVLQQMKHGKLPALGHFEQQNPHISLEDSPLVIDTEG
IDWPDQGAPRRAGVSSFGFSGTNAHVVLEAYRERRTFATHRGERVLVPLSARNAQGLRAQ
AVRLLEHLAQHAPDLAALAYTLQTGREAMATRALFMVDSPAQLQQQLQAWIGSEPGTDFG
AASMTAEAALAAGDTGQLAALWLAGAEEGDAFDWMRLYGEGPHPARIDLPTYAFGGERYW
LDAPAPAVGHSATAVAETAVAAYSEQWQEVDEPAPGPRMERLICLLGEPQLRQALVREVG
ELSPQTELIFIAADRSNGRDADGHYRVAAEDPLQLQEGLQPLLSAHGSSRVLYLWGMDDR
RWIADSRPIVALLKAMATTAAPVDRVLLAGRANDALERCHLESWIGIERSVGAVMPHCPV
EVAIDLPAPIGDDRRWVRRLWRQLGSGTASGSRLYRDGRVFRPMLVPASLDAAAEPLALE
RMHTVLITGGLGELGLLLAAELSSRAKKRTGDVLNLILNGRSPLSAAKRARLDSLHHGTC
RIFHLQADCADRPAMAAALAEVLPQSGPIDAVIHAAGLQARSSLFDSAPEAFEAVLNAKV
KTTLALDALLADRPLALICHFSSSSAMLGDMGACSYAMANRFQQAYARHMQAGRARRIVS
IHWPLWREGGMAVGDRESTAFYLKSSGLRMLDSAEGLTLLQRIVASEADQVLVLAGESAR
LQQLVDGINDPAAKPTAKPATANLAPHRPRSRPELKGLSLEQALLWDLRDLASRPLKAER
HTLGDDTNLADFGFDSISLAEYARLLSHHYGLKLTPELFFSHATLAKIAAHLLAQHRPAV
EVCYRSEGTRAAELSPMPTVAAAASGPAPNAGAIAIIGISGRFPGARNPDELWRLQVEGR
DAVGEIPADRYDWRDYYGDHREDPGKTRCIWMGSVPGVGEFDPLFFEISPREAKTLDPRQ
RLLLQESWNALEDAGIGARHLQAQRVGMFVGVEEGDFQRLAGDESLTSGHNGILASRLAY
FLNLTGPAMAINTACSSALVALHQAASSLRNDECEMAIAAGVNLIFSPDAFIGMTQAGML
SPDGKCYTFDRRANGMVPGEAVCCVVLKPLARAEADGDRIYGVLRGSGINYDGKTNGITA
PSGAAQQCLLEAVYRRAGIDIDAVEYIVTHGTGTQLGDPVEINALNDAFRGSRPGHCALT
STKTNVGHTFAASGLVSVISLLQAFRHDTIPASLHCEQENDYIHWQASPFYVNKANKAWP
RAGRDSERLGAVSAFGMSGTNAHVVLESYIRESDAAPFRRPCYLLVLSAKTAEALTARVE
QLGAALEQGGYRDDQLPSISYTLLEGRHHFRHRLALVAADLEEARYSLQQYLAGEKRPNL
FAGEVDRAFSAQKTIVRYLDQLLDDSRNAGDGEIRDLLSGLADCYRQGYDIDGRRLFAAV
RHGACEAPPRLSLPGYPFAREHYWPDIRRRRQQPAPLAAQGMAHLHPLVHCNVSTLARQR
FVSRFSGRETFLADHRIGDRLVFPATAYLELAREAIVRASELPPRQVALRNVVWLRPLAF
AAGGGDGEVALYCELAVNGHDSLSFRIYSLDNGTEQLHAQGDAQLTASAASPPQPVDLSA
LRARCNVSERSHDALYRDFESLGAHYGATFRGAAHLSIGPDLVVGQLSGQALDPGLDGVL
LPPGVLDSALHIAAALGTGAGGQGPAEPALPFALESLRLYGSVAQALSAGPLTVIAAYSE
ARGAGTVGKVDVRICDGGGECLVLLDGFSARKTASERQSAQVAEVTPLEDETAFGSLIRT
PFWSPLDHPGESIPAAAKPQLLLLGLPEAVVEGVRRQYGDQVTVLPGAPGECGAAAYRAA
ALSLFEWLQRRVGSHEGGYLQLFVGQGSDDLRLTALDAMLKTAMIENGAWRARLLVLDPA
MGDQAMIRVIGEQNRYHGNALMRVFANGSLYGRQWRTLAPESMPQNEATPFRDGGVYAIT
GGAGGLGLIFAEQIVGSCRNPVLYLVGRSAVTQPLQQAIDRLQARGAQVHYQSLDVSDAT
AVSRWIDRIDAEQGALHGVVHSAGVIRDGLILHKSAGEFEQVLAAKVAGIEALDEAIGER
PLDFLVCCSSQAAMGNLGQVDYAAANAYMDAFMHYRQDLAADGKRKGRSLSINWPLWRDG
GMKLAPVIEQQMRQRFGIAPMPTADGIGSLRQLLTGSVSAQGWVVYGELSRLADIGLPAD
VQPRRPAEPAPGRTAGAADIGDLELKKRIEAFVTGIVADVIQIDAAKIHPAEKFEVYGFD
SIMAVGVTHALEKHLGSLPKTLLFEHVNVAGLTDHFAVQYRDRFAAMFSGAVAQPATAAG
PAAAEPAPAQPLPLHRFAAANRGADGSAAQEGAPTASVERVEDSELEHYVAVIGLGGYYP
GASDMDGLWRNLANGIDCMSDFPAQRWDHDKLYYKNRKVLGKTTCINGAFIEDVDKFDYS
YFKMPKVYADHMSPEVRLFLQVAVQTFEDAGYSRETMLSRYGGDVGVLVGTMTNDYPYYG
FESNLFRGAMASGSGMATIPMTVSYFYGLTGPSLFIDTMCSSSLTCIHTACQMLKHDETK
MVLAGGLNLMYHPYTTVETSQGNFTSITSASVNSYGVGADGTVIGEGVGAVLLKRLDRAI
ADRDQIYGVIKGSAMTNAGERNGFNVPNPDLQTLAIRQAMDQANVHPSSISYVEGHGSGT
KLGDPIEVLGLNNAFRWATGDKQFCYLGSIKSNIGHLLAASGVAGLTKILLQIKHGQIVP
SIHSGQLNPDIDFADTPFVVPQQLVEWRRPQRTVNGRMQVFPRRAGLTSIAAGGMNAHMI
VEEYPAPADSGGRIPDDQLVFVFSVHKLSVLAENLTGFRDWLASSEAPLSRIAHTLQVGR
NNLRNRLAIRCRSRQALLDALGACIEGRYRAGADSKIFYRFQENDTAQPPDIDPDDPLIS
PLTRWLDGDKQVDWASLYAELPVRISLPVYRFEKPRCWYTEPAYESSILNPLMFSNKLHP
LVAQSNATLEPEAMFRTDFIEAELLDYVYGTAGGRRLSAFNFADVALAMPALVSRLGGRA
LSVSWAFEHDIADWATVAALEYRVFEIDSEQLELEFDCRRNDGQRVNLGFAVINPLADDA
PPLPQPLLDNAGALFNRQPSHACKRVSAEAVGQRLAQAGHDFAPYLDSVGELVIGQAGLL
LEGSPPAHRHNHHADNLQLPPDVATTIDKALYLLLDALGLPQGRAVVRTIERLCCYAKPA
GRFSVVLSEIVPADGALSLSLLVLDEQAQICVKADRVSLHLGQQELASLRRDHDLLAGAV
NATAGVRPSVEPAGDPGAAGRQAQDTEPTAGDGESGRGTRVLAFIQQALRDKLGFAAQEI
GESAQLQDLGLDSIMVVQLTDSLNKHFDTKLMPDLFYEKQRLGELAARLEAGLPQA