Protein Info for UW163_RS18765 in Ralstonia solanacearum UW163

Annotation: methylmalonate-semialdehyde dehydrogenase (CoA acylating)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01722: methylmalonate-semialdehyde dehydrogenase (acylating)
  • amino acids 22 to 498 (477 residues), 744 bits, E=3.3e-228
• PF00171: Aldedh
  • amino acids 30 to 494 (465 residues), 483 bits, E=4.2e-149

Best Hits

Swiss-Prot: 58% identical to MMSA_HUMAN: Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) from Homo sapiens

KEGG orthology group: K00140, methylmalonate-semialdehyde dehydrogenase [EC: 1.2.1.27] (inferred from 94% identity to rsl:RPSI07_mp0527)

MetaCyc: 69% identical to methylmalonate-semialdehyde dehydrogenase subunit (Burkholderia cepacia R34)
Methylmalonate-semialdehyde dehydrogenase (acylating). [EC: 1.2.1.27]

Predicted SEED Role

"Methylmalonate-semialdehyde dehydrogenase (EC 1.2.1.27)" in subsystem Isobutyryl-CoA to Propionyl-CoA Module or Valine degradation (EC 1.2.1.27)

MetaCyc Pathways

• myo-inositol degradation I (6/7 steps found)
• β-alanine degradation II (2/2 steps found)
• β-alanine degradation I (1/2 steps found)
• propanoyl-CoA degradation II (3/5 steps found)
• L-valine degradation I (5/8 steps found)
• myo-, chiro- and scyllo-inositol degradation (6/10 steps found)
• 2,4-dinitrotoluene degradation (2/7 steps found)

KEGG Metabolic Maps

• Inositol phosphate metabolism
• Propanoate metabolism
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.27

Use Curated BLAST to search for 1.2.1.27

Protein Sequence (515 amino acids)

>UW163_RS18765 methylmalonate-semialdehyde dehydrogenase (CoA acylating) (Ralstonia solanacearum UW163)
MSAVASLSSVPPAEPARTLPSVKLLIGGAFVESRSAEWREVVNPATQDVLARVPFATQAE
VDAAVRAAHAAFATWKHTPVGARMRIMLKYQALIREHLPRIARTLTAEQGKTLPDAEGDL
FRGLEVVEHACSVGSLQQGEFLENVAGAVDTYTLRQPLGVCAGITPFNFPAMIPLWMFPM
AIVCGNTFVLKPSEQDPLSTMLLVELALEAGVPPGVLNVVHGGKKVVDALCTHELVKAVS
FVGSTAVGTHVYRLAGEHGKRVQSMMGAKNHAVVLPDANREQTLNALVGAAFGAAGQRCM
ATSVAILVGAARQWVPALVEKARALKVNAGIEPGTDVGPVISRAARQRILGLIESGVHQG
ATLALDGRNVRVAGYADGNFIGPTVFTDVTTDMDIYRNEIFGPVLLVLTAPTLDEAIALV
NRNPFGNGVGLFTQSGAAARKFQSEIDVGQVGINIPIPVPVPYFSFTGSRGSKLGDLGPY
GKQVVQFYTQTKTVTARWFDDAVEAGSVNTTISLR