Protein Info for UW163_RS17175 in Ralstonia solanacearum UW163

Annotation: 4-hydroxybutyrate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00465: Fe-ADH
  • amino acids 8 to 368 (361 residues), 325.5 bits, E=3.9e-101
• PF13685: Fe-ADH_2
  • amino acids 14 to 105 (92 residues), 30.9 bits, E=2.4e-11
  • amino acids 132 to 276 (145 residues), 29.2 bits, E=8.2e-11

Best Hits

KEGG orthology group: None (inferred from 89% identity to rsl:RPSI07_mp0978)

Predicted SEED Role

"Alcohol dehydrogenase (EC 1.1.1.1)" in subsystem Fermentations: Mixed acid or Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 1.1.1.1)

MetaCyc Pathways

• superpathway of anaerobic sucrose degradation (16/19 steps found)
• heterolactic fermentation (15/18 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (15/19 steps found)
• 3-methylbutanol biosynthesis (engineered) (6/7 steps found)
• ethanol degradation II (3/3 steps found)
• mixed acid fermentation (12/16 steps found)
• ethanolamine utilization (4/5 steps found)
• pyruvate fermentation to isobutanol (engineered) (4/5 steps found)
• acetaldehyde biosynthesis I (1/1 steps found)
• L-phenylalanine degradation III (3/4 steps found)
• phytol degradation (3/4 steps found)
• L-isoleucine degradation II (2/3 steps found)
• L-leucine degradation III (2/3 steps found)
• L-valine degradation II (2/3 steps found)
• ethanol degradation I (1/2 steps found)
• pyruvate fermentation to ethanol II (1/2 steps found)
• (S)-propane-1,2-diol degradation (3/5 steps found)
• acetylene degradation (anaerobic) (3/5 steps found)
• L-tyrosine degradation III (2/4 steps found)
• salidroside biosynthesis (2/4 steps found)
• L-methionine degradation III (1/3 steps found)
• pyruvate fermentation to ethanol I (1/3 steps found)
• pyruvate fermentation to ethanol III (1/3 steps found)
• phenylethanol biosynthesis (2/5 steps found)
• cytidine-5'-diphosphate-glycerol biosynthesis (1/4 steps found)
• serotonin degradation (3/7 steps found)
• superpathway of fermentation (Chlamydomonas reinhardtii) (4/9 steps found)
• butanol and isobutanol biosynthesis (engineered) (3/8 steps found)
• superpathway of N-acetylneuraminate degradation (13/22 steps found)
• superpathway of Clostridium acetobutylicum solventogenic fermentation (6/13 steps found)
• superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (8/17 steps found)
• noradrenaline and adrenaline degradation (4/13 steps found)
• L-tryptophan degradation V (side chain pathway) (1/13 steps found)

KEGG Metabolic Maps

• 1- and 2-Methylnaphthalene degradation
• 3-Chloroacrylic acid degradation
• Drug metabolism - cytochrome P450
• Fatty acid metabolism
• Glycine, serine and threonine metabolism
• Glycolysis / Gluconeogenesis
• Metabolism of xenobiotics by cytochrome P450
• Retinol metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.1

Use Curated BLAST to search for 1.1.1.1

Protein Sequence (377 amino acids)

>UW163_RS17175 4-hydroxybutyrate dehydrogenase (Ralstonia solanacearum UW163)
MAYIYYLTHIHLGYEALARLPAECARVGIRRPLIVTDKGVVAAGLVQCALDMLDAGHVPV
FDDTPSNPTEAMVMAAAACYRHHDCDGLIAVGGGSAIDLAKGAALAATHAGGLARYATVE
GGSDRITDAVPPLIAVPTTAGSGSEVARGAALIVEDGRKLSFHSWHLMPRSAICDPGLTL
GLPATLTAGTGMDAIAHCIETFLAPAFNPPAEGIALDGLERAWAHIERATQDGSDRDARL
QMMSASLQGAMAFQKGGGCAHALSHAIGGETRLHHGTLNAVLLPAVLRFNETAASVVQNR
RYVRLRRAMRLPAEADIAQAVFEMNVRLGLPTGLKQLGVDDSMFDRVIGAARTDYCHRTN
PREATPADYRRLLSESL