Protein Info for UW163_RS14450 in Ralstonia solanacearum UW163

Annotation: lysine-specific permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 509 transmembrane" amino acids 25 to 47 (23 residues), see Phobius details amino acids 55 to 77 (23 residues), see Phobius details amino acids 98 to 120 (23 residues), see Phobius details amino acids 126 to 151 (26 residues), see Phobius details amino acids 163 to 185 (23 residues), see Phobius details amino acids 204 to 224 (21 residues), see Phobius details amino acids 249 to 269 (21 residues), see Phobius details amino acids 290 to 313 (24 residues), see Phobius details amino acids 351 to 368 (18 residues), see Phobius details amino acids 374 to 397 (24 residues), see Phobius details amino acids 418 to 438 (21 residues), see Phobius details amino acids 450 to 470 (21 residues), see Phobius details PF00324: AA_permease" amino acids 24 to 480 (457 residues), 447.7 bits, see alignment E=4.9e-138 PF13520: AA_permease_2" amino acids 26 to 436 (411 residues), 132.1 bits, see alignment E=2.8e-42

Best Hits

Swiss-Prot: 64% identical to LYSP_ECOLI: Lysine-specific permease (lysP) from Escherichia coli (strain K12)

KEGG orthology group: K03293, amino acid transporter, AAT family (inferred from 99% identity to rsc:RCFBP_11766)

MetaCyc: 64% identical to lysine:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-58

Predicted SEED Role

"Lysine-specific permease" in subsystem YeiH

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (509 amino acids)

>UW163_RS14450 lysine-specific permease (Ralstonia solanacearum UW163)
MHTPITPTGLEGQSELRRRLRARHLMMIALGGAIGTGLFVASGASIAQAGPGGALLTYTL
IGAMVYCLMTSLGELAVHLPVSGSFVTYSRLYVEEGFGFALGWNYWFALAVSVAVELAAA
QLVMKYWFPGVSGMVWSAAFLLLMFALNAFSVRGFGEAEYWFSMIKVVTIVVFLLIGLAM
IFGIMRGGPQLGWHNFTVGDAPFVGGLPAMIGVAMIAGFSFQGVETIGVAAGEAEDPART
IPRGIRQTFWRILLFYVLAILIIGVLLPYTDPNLLRNEATDIGVSPFALVFQHAGLAFAA
GMMNAVVLTALLSSGTSSLYVSTRILYDLALEGQAPRWFAKVSGNGVPHRALLATSAVGA
LCFFSSLFGDQVVYLWLLNTSAVTCFIAWFGIALAHYRFRKGFLHQGHTVEQLEYRSPFF
PFGPIMVAALCVIIILGQNTKALFAPLDNFGPFVATYCGVFLFVAIWLGYRWRYKTRFVR
YAQMQFSPRHLHAAKAEDGGTALPGVAAD