Protein Info for UW163_RS13935 in Ralstonia solanacearum UW163

Annotation: type II toxin-antitoxin system HipA family toxin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 445 TIGR03071: HipA N-terminal domain" amino acids 5 to 107 (103 residues), 106.2 bits, see alignment E=4e-35 PF13657: Couple_hipA" amino acids 6 to 107 (102 residues), 81.7 bits, see alignment E=4.9e-27 PF07804: HipA_C" amino acids 155 to 402 (248 residues), 172 bits, see alignment E=1.5e-54

Best Hits

KEGG orthology group: K07154, (no description) (inferred from 98% identity to rsc:RCFBP_11901)

Predicted SEED Role

"HipA protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (445 amino acids)

>UW163_RS13935 type II toxin-antitoxin system HipA family toxin (Ralstonia solanacearum UW163)
MARPELHLWMNGEHVGVWTASRAGVPILRYDEGWLRSPNVRPLSLSLPIPAGVPELRGPV
VDDYFDNLLPDAQPIRERVRRRFGLASTEAAELLAAIGRDCVGAVQLLPPGMAPAGFDRI
DSEPLSDQQVDALLRNLTRLPAPGEDTDDLDAFRISIAGAQEKTALLRIGDTWHRPLGAT
PTTHILKLPLGLIGNLRADMQDSVDNEWLCAQLLAAWGLEVAHTEIARFGARKVLAVERF
DRRWMADRGWIARLPQEDFCQATGTPAHRKYESDGGPGLRACLDLLSASEQAIDDKRRFV
LAQLAFWLLAATDGHAKNFSLAIGRGGRFRMTPLYDVLSVWPIVGDGPNQLSPYRARLAM
ALRGKNAHARLADIRVRHWQALAAQSGVPDAFARMQALVERVPAGLDQVGAILPPDFSGR
VWDSVRAGVLAQAERFISELAAVTP