Protein Info for UW163_RS12925 in Ralstonia solanacearum UW163

Annotation: myo-inosose-2 dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR04379: myo-inosose-2 dehydratase
  • amino acids 13 to 306 (294 residues), 381.7 bits, E=1.3e-118
• PF01261: AP_endonuc_2
  • amino acids 41 to 304 (264 residues), 115.4 bits, E=1.9e-37

Best Hits

Swiss-Prot: 47% identical to MOCC_RHIML: Rhizopine catabolism protein MocC (mocC) from Rhizobium meliloti

KEGG orthology group: K03335, inosose dehydratase [EC: 4.2.1.44] (inferred from 99% identity to rsc:RCFBP_20183)

Predicted SEED Role

"Inosose dehydratase (EC 4.2.1.44)" in subsystem Inositol catabolism (EC 4.2.1.44)

MetaCyc Pathways

• myo-inositol degradation I (6/7 steps found)
• myo-, chiro- and scyllo-inositol degradation (6/10 steps found)

KEGG Metabolic Maps

• Inositol phosphate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.44

Protein Sequence (319 amino acids)

>UW163_RS12925 myo-inosose-2 dehydratase (Ralstonia solanacearum UW163)
MTQTPHPTGRWPVRIGINPISWSNDDLPSLGGDTPLETALREGAAIGYQGFELGNKFPRE
PQALRAKLAEFGVACVSGWYSGQLAEGTLDDELKRCDAHMRKLQAQGCGVVVYGEVAGSI
QGRIDTPLGKRPRFVSDAQWQGYARRLDAFGAHLRQTYGLRLAYHHHMGAYVESPEDVDR
LMAQTTDNVGLLFDTGHAYFGATRNGAPADPVAQLSRHVHRVVHVHCKDVRAPLIGAACN
DGWSFLNAVLAGAFTVPGDGCIDFEAVLRVLHDAGYAGWLVVEAEQDPAVAPPYAYAKKG
YDTLAGIVRRIETAAEEAA