Protein Info for UW163_RS10945 in Ralstonia solanacearum UW163

Annotation: acyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02770: Acyl-CoA_dh_M
  • amino acids 137 to 234 (98 residues), 74.5 bits, E=1.3e-24
• PF00441: Acyl-CoA_dh_1
  • amino acids 250 to 398 (149 residues), 127.9 bits, E=7.4e-41
• PF08028: Acyl-CoA_dh_2
  • amino acids 267 to 372 (106 residues), 55.6 bits, E=1.4e-18

Best Hits

KEGG orthology group: K00249, acyl-CoA dehydrogenase [EC: 1.3.99.3] (inferred from 98% identity to rsc:RCFBP_11365)

Predicted SEED Role

"Isovaleryl-CoA dehydrogenase (EC 1.3.8.4)" (EC 1.3.8.4)

MetaCyc Pathways

• L-leucine degradation I (5/6 steps found)

KEGG Metabolic Maps

• Fatty acid metabolism
• Propanoate metabolism
• Valine, leucine and isoleucine degradation
• beta-Alanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.3.8.4, 1.3.99.3

Use Curated BLAST to search for 1.3.8.4 or 1.3.99.3

Protein Sequence (420 amino acids)

>UW163_RS10945 acyl-CoA dehydrogenase (Ralstonia solanacearum UW163)
MHFDYSPKVKAMQARLLDFFDRHIYPNEHRFHEEIEANRRAGNAWIPTRVIEEFKPLARQ
AGLWNLFLPRSPRAPEGLSNLEYAPLCEIMGRVPWAPEVFNCSAPDTGNMETLERYACEA
LKDRWLEPLLRGEIRSAFLMTEPAVASSDATNIECRIERQGDEYVINGRKWWSSGAGDPR
CAVYIVMGKTNPDAGKHEQQSMIVVPADAPGITVLRPLSVFGYDDAPHGHMEVDLKNVRV
PAANILLGEGRGFEIAQGRLGPGRIHHCMRSIGVAERALELMCQRLCARVAFGKPIAQHS
VWHERIAEARCMIEQARLLTLKAAYMMDTVGNKVARAEIAMIKVVAPNIACQIVDWAIQA
HGGGGVSGDFPLASAYAHQRTLRLADGPDEVHRAAIAKLELAKHLHKLADVVDMPIARGA