Protein Info for UW163_RS08295 in Ralstonia solanacearum UW163
Annotation: aminodeoxychorismate synthase component I
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K03342, para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC: 2.6.1.85 4.1.3.38] (inferred from 98% identity to rsc:RCFBP_10814)Predicted SEED Role
"Para-aminobenzoate synthase, aminase component (EC 2.6.1.85) / Aminodeoxychorismate lyase (EC 4.1.3.38)" in subsystem Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. or Folate Biosynthesis (EC 2.6.1.85, EC 4.1.3.38)
MetaCyc Pathways
- superpathway of tetrahydrofolate biosynthesis and salvage (11/12 steps found)
- L-citrulline biosynthesis (8/8 steps found)
- L-glutamate and L-glutamine biosynthesis (7/7 steps found)
- superpathway of tetrahydrofolate biosynthesis (9/10 steps found)
- superpathway of L-citrulline metabolism (10/12 steps found)
- L-asparagine biosynthesis III (tRNA-dependent) (4/4 steps found)
- ammonia assimilation cycle III (3/3 steps found)
- superpathway of chorismate metabolism (43/59 steps found)
- 4-aminobenzoate biosynthesis I (2/2 steps found)
- L-glutamate biosynthesis I (2/2 steps found)
- L-glutamine degradation I (1/1 steps found)
- glutaminyl-tRNAgln biosynthesis via transamidation (3/4 steps found)
- 4-aminobenzoate biosynthesis II (1/2 steps found)
- superpathway of candicidin biosynthesis (3/11 steps found)
- chloramphenicol biosynthesis (1/9 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.6.1.85
Use Curated BLAST to search for 2.6.1.85 or 4.1.3.38
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (628 amino acids)
>UW163_RS08295 aminodeoxychorismate synthase component I (Ralstonia solanacearum UW163) MQSPDAGAPFALLDDATSTGAPCSRWYTGYAGEIVRPPGRLEGLDDALRGAWAEGLHALV MAPYAFGRPLVGLAPAISASAPSPLPGHDGRLRVLLFRSMQVLSAAEVEALFDAWPEAGG AAGLFDCAASVDHDAYVRAIARIQDWIAAGDTYEVNYTYRLRMTAFGAPFALYRRLRARQ PVPYGALIGLPEGGAVLSCSPELFFSHRAGSLVARPMKGTAPASGDPEVDETRAVALAAD EKNRAENLMIVDLLRNDLGRLARPGSVRVPALFEVTPYGSVLQMTSTVQAQIPPETGLAD CLAALFPCGSITGAPKRRTMEIIDALEPEPRGLYTGAIGWIDAPVGDRAMGDACFSVAIR TLVLGAAGTDGLRAGELGIGSGIVYDSVADDEYAECRLKARFVTALDPGLSLFETMRATR AEGVPLLDRHLARLEHSARAFGFGFDRDALVREVARVCGTLPEDGAHRMRLSLQHSGAFS VTAAPLSPLPAAWDAPVRLHIAPQAREAVHSLPHHKTSLRAAYDAAWQAAEREGAFDAVF FNADGTLAEGGRSTVLVKLEGQWWTPPLSAGVLPGVMRGVLLDDARPWLGAPLRERVLTR AEVARAEAIAVCNALRGVVPAHFEPPLA