Protein Info for UW163_RS07875 in Ralstonia solanacearum UW163

Annotation: HlyD family secretion protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 391 transmembrane" amino acids 38 to 57 (20 residues), see Phobius details PF16576: HlyD_D23" amino acids 73 to 317 (245 residues), 60.2 bits, see alignment E=2.8e-20 PF13533: Biotin_lipoyl_2" amino acids 77 to 123 (47 residues), 50.6 bits, see alignment 1.9e-17 PF13437: HlyD_3" amino acids 243 to 357 (115 residues), 56.1 bits, see alignment E=8.1e-19

Best Hits

KEGG orthology group: K03543, multidrug resistance protein A (inferred from 96% identity to rsc:RCFBP_10724)

Predicted SEED Role

"Membrane fusion component of tripartite multidrug resistance system" in subsystem Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (391 amino acids)

>UW163_RS07875 HlyD family secretion protein (Ralstonia solanacearum UW163)
MTQAMEQHQDMDHPARHGGAGTAPPQPAGRLRGRSRRVAMSVAVLALLGAAGGLAHYELR
GKYVENTDDAYIQADIVTVAPKVSGYVERVDVANNQEVRAGQRLLRIDPREYAAQLAQYQ
AQVEAANASADNARAQLATQQAAIAQAQAQLQSAEHDAQFTASQTQRYASLVASGAETRD
RLSTLQNQAAQARANAAAQRAALTKATLEIAALQAQLRQAEAQAKTARAQAAVAEVNLAA
TELRASTDGRVGDSQVRIGQFVSAGTRLMSVVPAHLYITANFKETQLSHMRIGQPVHVHV
DAFPDEAIEGHVESLSPGTGAQFSLLPPQNATGNFIKIVQRVPVRIALDVTNDQLKPLLA
AGMSVTVDVDTLAQGQPQRVSRPQPGHGALL