Protein Info for UW163_RS07100 in Ralstonia solanacearum UW163

Annotation: FUSC family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 737 transmembrane" amino acids 25 to 52 (28 residues), see Phobius details amino acids 65 to 84 (20 residues), see Phobius details amino acids 90 to 108 (19 residues), see Phobius details amino acids 115 to 133 (19 residues), see Phobius details amino acids 139 to 159 (21 residues), see Phobius details amino acids 387 to 405 (19 residues), see Phobius details amino acids 411 to 429 (19 residues), see Phobius details amino acids 441 to 470 (30 residues), see Phobius details amino acids 482 to 501 (20 residues), see Phobius details amino acids 512 to 532 (21 residues), see Phobius details amino acids 607 to 624 (18 residues), see Phobius details PF12805: FUSC-like" amino acids 69 to 336 (268 residues), 219 bits, see alignment E=7.2e-69 PF13515: FUSC_2" amino acids 403 to 524 (122 residues), 75.4 bits, see alignment E=4.7e-25

Best Hits

KEGG orthology group: None (inferred from 99% identity to rsc:RCFBP_10567)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (737 amino acids)

>UW163_RS07100 FUSC family protein (Ralstonia solanacearum UW163)
MDYVHDPRTFLYSHYVSRGVRTATGVIGLTLLALLAMDLQGAMVVSIGALCTSQMDLPSP
LRHKFNELLACVLLTTLVTFIVAVATPYAVLPAVIVVVSFLAGLMAVYGNKTLSLQFAAL
FVMTLTFTEEFAFREALEHTAQFFLGAAGYMAFAMAVAWSQRRRIKEQVLAECLYELAVY
VERKAGFYDTALDFDAQFNALVRQQISVADKQQVARDFVFRDNRGASDGRLVQIHMRMLD
LYEYLLSTNTDYPLLRQWLADAEIMRLLRDIIERMRLDLEALAYAVGRDQPSPTPMSYDK
EMAAIDAAVDELEHGHHAIPLEAIAALEESVATVRGAIRLMAQLHAATATQVELSSVLLR
PDMTPFLTRQKYELSLVLEAFNWRSPVLRFALRTAMAVAAGLWIADHLPYASHGYWVLLT
IVVILKPTFSMTRQRNVDRVLGTLIGCVIAAVLLRYVHSTWLLLAALYLSTAASAAFVTV
RYRYTAAAAAVQVLIQINLLLPGSKGAIGERLVDTLIGAAIATAFSYVLPAWEYRNLPKL
VDDVLRTNRRFIESARDLLLGSLKDDFAYRVQRKQFMDTLTGLIAAFARMLDEPKSRHRA
VDNLNRFIVQNYLVAAHVAAVRILVSQRAQELDEADTRALIGQTVEAALESLARAKERFD
QAIHEGGWGVRPRDTQELGAADFADQSARSRMIDAATHPDSLSAMHLLERRLQALRADTA
KIALRCGALGRALRLAD