Protein Info for UW163_RS04650 in Ralstonia solanacearum UW163

Annotation: copper-translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 749 transmembrane" amino acids 99 to 120 (22 residues), see Phobius details amino acids 126 to 145 (20 residues), see Phobius details amino acids 159 to 179 (21 residues), see Phobius details amino acids 187 to 204 (18 residues), see Phobius details amino acids 342 to 364 (23 residues), see Phobius details amino acids 371 to 395 (25 residues), see Phobius details amino acids 689 to 709 (21 residues), see Phobius details amino acids 715 to 731 (17 residues), see Phobius details PF00403: HMA" amino acids 15 to 73 (59 residues), 46.1 bits, see alignment 1.1e-15 TIGR01511: copper-translocating P-type ATPase" amino acids 140 to 732 (593 residues), 578.6 bits, see alignment E=3.2e-177 TIGR01525: heavy metal translocating P-type ATPase" amino acids 159 to 731 (573 residues), 609.5 bits, see alignment E=1.5e-186 TIGR01494: HAD ATPase, P-type, family IC" amino acids 197 to 444 (248 residues), 145.9 bits, see alignment E=2.7e-46 amino acids 525 to 708 (184 residues), 133.9 bits, see alignment E=1.2e-42 PF00122: E1-E2_ATPase" amino acids 225 to 405 (181 residues), 198 bits, see alignment E=2e-62 PF00702: Hydrolase" amino acids 422 to 643 (222 residues), 115.3 bits, see alignment E=9.8e-37

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 98% identity to rsc:RCFBP_10117)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (749 amino acids)

>UW163_RS04650 copper-translocating P-type ATPase (Ralstonia solanacearum UW163)
MTTASLADAASLDLEIQGMTCAACAGRVERALRAVPGVVAASVNLATERARIQRADDVSG
DALVAAVVAAGYEARIASDEVTAAPAGVEPGFWDGPGPVWVSAALSLPLVAPMVAGWLGA
GWMLPAWLQWLLATPVQGVIGARFYRAGWKALRAGAGNMDLLVALGTSAAYGLSLWLWWR
ADAGDMPHLYFESAAVVITLVRLGKWLEARAKRQTAQAIRALQALRPDTARVLGADGTLR
DVPVARVRVGDAVSVRAGERIPVDGTVAEGASHVDQSMLTGESLPVPKRAGDHVTAGAIA
TDGVLLVRTTAIGADTMLSRIIRLVEDAQAAKPPIQQLVDRVSAVFVPAVLAAALVTLIG
WMIAGAGWEHAIVNAVAVLVIACPCALGLATPSAIMAGTGAGARRGILIADAQALERARQ
VDFVVFDKTGTLTVGQPRVAAVEAAPGLDGDAVLDQLAALQAEHTHPLAQATRDHAAARG
RTIAPARSPEVLAGRGVRGVVDGAVLSLGNARWMDELRLDRTRLQARADALEAQGHTVSW
LAQGEAGGGVQLRGLIAFGDALKPGAREAVAELHRRGIRTALVTGDNAGAARGVAEALGI
EAVAAQVLPQDKAARVAAWQQGGHVVAMVGDGINDAPALAAADVGIAMATGTDVAMQAAG
ITLMRGEPRLVPAALELSQRTVAKIRQNLFWAFVYNVVGIPLAACGLLSPTFAGAAMAFS
SVSVVTNALMLRRWRPRWESATATGDRAS