Protein Info for UW163_RS03970 in Ralstonia solanacearum UW163

Annotation: sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 448 transmembrane" amino acids 21 to 42 (22 residues), see Phobius details amino acids 48 to 67 (20 residues), see Phobius details amino acids 80 to 99 (20 residues), see Phobius details amino acids 108 to 134 (27 residues), see Phobius details amino acids 155 to 178 (24 residues), see Phobius details PF02518: HATPase_c" amino acids 313 to 430 (118 residues), 49.3 bits, see alignment E=3.2e-17

Best Hits

KEGG orthology group: K15011, two-component system, sensor histidine kinase RegB [EC: 2.7.13.3] (inferred from 98% identity to rsc:RCFBP_21406)

Predicted SEED Role

"Sensor histidine kinase PrrB (RegB) (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (448 amino acids)

>UW163_RS03970 sensor histidine kinase (Ralstonia solanacearum UW163)
MLSTLPLAAPPLDTSSLRRLFWLRWILLATQLILMLLAPLIFGVQLPVVPLLSVMGLHAV
FNLLTGWRVRRDRPIRHIEITAQLLVDLTALSALLYFTGGATNPFVSFYLPALAIAAAML
PIAHVVGLTLYALAAYSMMLGNYIPLNLLNQADAVAYHLAGMWIDFVASSAMIAGFTARL
SAALREREAELADARERLLREQRIEALVSQGASVAHEMGTPLSTVAVIAGELQHDARQPD
SPLVPYREDLRAIEQQLELCRAALARLQRKPNDGTPEPLGLWLPAFTQTWQLRHPDIRLH
TESSPVAQAVELDAVSVGQILTILLDNAARSQQQAGRDQVPLLLTARIDAGADTLREAPR
QIVLSVVDTGLGLPEDLRTALGRTPVPSRHGGHGIGLYLAATTARRLGGTVELRPNPPQG
AIAELRLPVAGPTVQSAAPVIGAPTLFT