Protein Info for UW163_RS03400 in Ralstonia solanacearum UW163

Annotation: aldehyde dehydrogenase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 24 to 480 (457 residues), 418.9 bits, E=1.1e-129

Best Hits

KEGG orthology group: K00128, aldehyde dehydrogenase (NAD+) [EC: 1.2.1.3] (inferred from 98% identity to rsc:RCFBP_21293)

MetaCyc: 66% identical to L-aminoadipate-semialdehyde dehydrogenase (Pseudomonas putida)
L-aminoadipate-semialdehyde dehydrogenase. [EC: 1.2.1.31]

Predicted SEED Role

"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)

MetaCyc Pathways

• ethanol degradation II (3/3 steps found)
• ethanol degradation IV (3/3 steps found)
• superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (6/8 steps found)
• phytol degradation (3/4 steps found)
• ethanol degradation III (2/3 steps found)
• hypotaurine degradation (2/3 steps found)
• methylglyoxal degradation IV (2/3 steps found)
• methylglyoxal degradation V (2/3 steps found)
• L-lactaldehyde degradation (aerobic) (1/2 steps found)
• mitochondrial NADPH production (yeast) (3/5 steps found)
• superpathway of methylglyoxal degradation (5/8 steps found)
• fatty acid α-oxidation I (plants) (2/4 steps found)
• histamine degradation (1/3 steps found)
• 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
• lactate biosynthesis (archaea) (2/5 steps found)
• octane oxidation (2/5 steps found)
• L-tryptophan degradation X (mammalian, via tryptamine) (1/4 steps found)
• putrescine degradation III (1/4 steps found)
• serotonin degradation (3/7 steps found)
• dopamine degradation (1/5 steps found)
• ceramide degradation by α-oxidation (2/7 steps found)
• sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
• alkane oxidation (1/6 steps found)
• L-rhamnose degradation II (2/8 steps found)
• aromatic biogenic amine degradation (bacteria) (2/8 steps found)
• limonene degradation IV (anaerobic) (1/7 steps found)
• L-lysine degradation V (2/9 steps found)
• noradrenaline and adrenaline degradation (4/13 steps found)
• superpathway of fucose and rhamnose degradation (3/12 steps found)
• ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)
• superpathway of L-lysine degradation (11/43 steps found)

KEGG Metabolic Maps

• 1,2-Dichloroethane degradation
• 3-Chloroacrylic acid degradation
• Arginine and proline metabolism
• Ascorbate and aldarate metabolism
• Butanoate metabolism
• Fatty acid metabolism
• Glycerolipid metabolism
• Glycolysis / Gluconeogenesis
• Histidine metabolism
• Limonene and pinene degradation
• Lysine biosynthesis
• Lysine degradation
• Propanoate metabolism
• Pyruvate metabolism
• Tryptophan metabolism
• Urea cycle and metabolism of amino groups
• Valine, leucine and isoleucine degradation
• beta-Alanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.22, 1.2.1.3

Use Curated BLAST to search for 1.2.1.22 or 1.2.1.3 or 1.2.1.31

Protein Sequence (503 amino acids)

>UW163_RS03400 aldehyde dehydrogenase family protein (Ralstonia solanacearum UW163)
MPLSPEALLQRLHLDTLIGGDGPLAACSPIDGAVLARLPVETAADADRIVAQAHAAFQRW
RTVPAPRRGELVRLLGEELRAHKADLGALVTLETGKITQEGLGEVQEMIDICDFAVGLSR
QLYGLTIASERPAHRMMETWHPLGPCLVITAFNFPVAVWAWNTALALVCGDPVVWKPSEK
TPLTALAVERLFLRACQRFGEAPPHLAQVAIGGRDLGEALARHPGIPLVSATGSTGMGRA
VAQAAAPRFARTLLELGGNNAAIVCASADLALAERAIAFAAMGTAGQRCTSLRRLFVQRP
VYASLVPRLTALYAHVPVGDPREDGTLVGPLIDRHAYERMQAALARARAEGGTVHGGERI
TVGTSDGAYYVRPALVEMPAQGGVVCEETFAPILHAMPFDTLDEAIALNNAVPHGLSSSL
FTLDMREAERFVSATGSDCGIANVNIGPSGAEIGGAFGGEKDTGGGREAGSDAWKAYMRR
ATNTVNYGTALPLAQGIRFEVGG