Protein Info for UW163_RS02260 in Ralstonia solanacearum UW163

Annotation: 3-oxoacyl-ACP reductase FabG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01370: Epimerase
  • amino acids 3 to 71 (69 residues), 32.9 bits, E=1.2e-11
• PF00106: adh_short
  • amino acids 3 to 193 (191 residues), 184.1 bits, E=5.5e-58
• PF08659: KR
  • amino acids 4 to 182 (179 residues), 82.3 bits, E=1.1e-26
• PF03807: F420_oxidored
  • amino acids 8 to 54 (47 residues), 22.8 bits, 2.9e-08
• PF13561: adh_short_C2
  • amino acids 12 to 237 (226 residues), 181 bits, E=7.6e-57

Best Hits

Swiss-Prot: 43% identical to FABG4_BRANA: 3-oxoacyl-[acyl-carrier-protein] reductase 4 (Fragment) (bkr4) from Brassica napus

KEGG orthology group: K00059, 3-oxoacyl-[acyl-carrier protein] reductase [EC: 1.1.1.100] (inferred from 98% identity to rsc:RCFBP_21049)

MetaCyc: 38% identical to 4-oxopentanoyl-CoA 4-dehydrogenase (Pseudomonas putida KT2440)
1.1.1.M44 [EC: 1.1.1.M44]

Predicted SEED Role

"3-oxoacyl-[ACP] reductase (EC 1.1.1.100)" (EC 1.1.1.100)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (50/53 steps found)
• palmitate biosynthesis III (28/29 steps found)
• superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
• palmitate biosynthesis II (type II fatty acid synthase) (29/31 steps found)
• anteiso-branched-chain fatty acid biosynthesis (30/34 steps found)
• even iso-branched-chain fatty acid biosynthesis (30/34 steps found)
• odd iso-branched-chain fatty acid biosynthesis (30/34 steps found)
• tetradecanoate biosynthesis (mitochondria) (23/25 steps found)
• superpathway of unsaturated fatty acids biosynthesis (E. coli) (19/20 steps found)
• octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) (12/12 steps found)
• oleate biosynthesis IV (anaerobic) (13/14 steps found)
• palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) (9/9 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (14/16 steps found)
• biotin biosynthesis I (13/15 steps found)
• 8-amino-7-oxononanoate biosynthesis IV (5/5 steps found)
• cis-vaccenate biosynthesis (5/5 steps found)
• fatty acid elongation -- saturated (5/5 steps found)
• gondoate biosynthesis (anaerobic) (4/4 steps found)
• 8-amino-7-oxononanoate biosynthesis I (9/11 steps found)
• (5Z)-dodecenoate biosynthesis I (5/6 steps found)
• stearate biosynthesis II (bacteria and plants) (5/6 steps found)
• (5Z)-dodecenoate biosynthesis II (4/6 steps found)
• stearate biosynthesis IV (4/6 steps found)
• petroselinate biosynthesis (2/6 steps found)
• 4-oxopentanoate degradation (3/9 steps found)
• 2-allylmalonyl-CoA biosynthesis (2/8 steps found)
• streptorubin B biosynthesis (20/34 steps found)
• mycolate biosynthesis (25/205 steps found)
• superpathway of mycolate biosynthesis (26/239 steps found)

KEGG Metabolic Maps

• Biosynthesis of unsaturated fatty acids
• Fatty acid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.100

Use Curated BLAST to search for 1.1.1.100 or 1.1.1.M44

Protein Sequence (238 amino acids)

>UW163_RS02260 3-oxoacyl-ACP reductase FabG (Ralstonia solanacearum UW163)
MRALVTGGSGVLGQAISEALAQAGHEVWVHANRHLEQAEAVAQRIVAAGGAAHAIAFDVT
DAQATEAALARALDGAPVQILVNNAGVHDDAPMAGMTQQQWRRVIDVSLNGFFNVTQPLL
MPMIRTRWGRIVNMASVAGVMGNRGQANYAAAKAGLIGATKSLAQELASRGITVNAVAPG
IIASPMAEEAFPAERIKQLVPARRAGQPEEVAGMVAYLVSDAAAYVTGQVLSINGGLA