Protein Info for UW163_RS01840 in Ralstonia solanacearum UW163

Annotation: molecular chaperone SurA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 495 signal peptide" amino acids 1 to 43 (43 residues), see Phobius details PF13623: SurA_N_2" amino acids 87 to 167 (81 residues), 30.5 bits, see alignment E=9.6e-11 PF09312: SurA_N" amino acids 87 to 204 (118 residues), 138.3 bits, see alignment E=4.3e-44 PF13624: SurA_N_3" amino acids 89 to 203 (115 residues), 50.7 bits, see alignment E=5.7e-17 PF13616: Rotamase_3" amino acids 233 to 338 (106 residues), 67.8 bits, see alignment E=3.8e-22 amino acids 347 to 446 (100 residues), 90 bits, see alignment E=4.9e-29 PF00639: Rotamase" amino acids 242 to 335 (94 residues), 70.9 bits, see alignment E=4.4e-23 amino acids 355 to 445 (91 residues), 83.4 bits, see alignment E=5.7e-27 PF13145: Rotamase_2" amino acids 256 to 343 (88 residues), 33.1 bits, see alignment E=2.7e-11 amino acids 354 to 453 (100 residues), 32.3 bits, see alignment E=4.6e-11

Best Hits

Swiss-Prot: 94% identical to SURA_RALSO: Chaperone SurA (surA) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K03771, peptidyl-prolyl cis-trans isomerase SurA [EC: 5.2.1.8] (inferred from 99% identity to rsc:RCFBP_20965)

Predicted SEED Role

"Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8)" in subsystem Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (495 amino acids)

>UW163_RS01840 molecular chaperone SurA (Ralstonia solanacearum UW163)
MACKSTAVRSATRVAPTRRLGMVTGALVALMAGAALLPAAHAQQTQKKSAPLRGIFATPD
ASPSQPLLRGTLPGPSTASGAARSQLVDEVVAVVNTDIITRRELLDRADLVERTLQAQNR
PMPARADLLGEVLEQLILERVQAQTAKESGIRVSDADVDRAVESVAQRNNLSVPQLKSKL
AQSGLAYDKYREDLRQEILLARLRDREVDSKVQVFDGEIDNFLAQQGGGATGEAQEYNVA
QILVPVAEDASAEQKAAARGKAENLLKQAQGGADFAKLARDNSSGPETAQGGELGLRSIG
RLPTQFANAVVDLKPGQLAGQVIESPAGFHVLKLVDKRAPGTAASAKVAQTQVRHILIKT
GPTMSADDARRQLAGLRDRIVHGYDFSDAARRYSQDTSASAGGELGWVSPGQLVPEFEQA
MNLLKPGEVSQPVQSQFGVHLIQVEGRREAEVPVDRQRDYARSVIREQKIQAAYEDWLRQ
LRDSAHVEYRVNRQQ