Protein Info for UW163_RS00970 in Ralstonia solanacearum UW163

Annotation: hybrid sensor histidine kinase/response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 200 400 600 800 1000 1200 1400 1600 1800 2039 transmembrane" amino acids 256 to 273 (18 residues), see Phobius details PF01627: Hpt" amino acids 757 to 859 (103 residues), 50.7 bits, see alignment 3.6e-17 amino acids 1062 to 1152 (91 residues), 37 bits, see alignment (E = 6.8e-13) amino acids 1257 to 1345 (89 residues), 47.5 bits, see alignment (E = 3.5e-16) PF02518: HATPase_c" amino acids 1602 to 1737 (136 residues), 56.4 bits, see alignment 8e-19 PF01584: CheW" amino acids 1742 to 1871 (130 residues), 75.7 bits, see alignment 5.8e-25 PF00072: Response_reg" amino acids 1914 to 2025 (112 residues), 87.5 bits, see alignment 1.4e-28

Best Hits

KEGG orthology group: K02487, type IV pili sensor histidine kinase and response regulator K06596, chemosensory pili system protein ChpA (sensor histidine kinase/response regulator) (inferred from 97% identity to rsc:RCFBP_20743)

Predicted SEED Role

"Signal transduction histidine kinase CheA (EC 2.7.3.-)" in subsystem Bacterial Chemotaxis or Flagellar motility or Two-component regulatory systems in Campylobacter (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (2039 amino acids)

>UW163_RS00970 hybrid sensor histidine kinase/response regulator (Ralstonia solanacearum UW163)
MHHPSSAQPESASLEAVGDVSAARPASSVPARDLSALAWVAPNMRAALDDAVREFSEYVA
DVVANPEVLGARDTTSLRLAGQYLHQAAGALLIVGLRGIDVYGQAAKRLLEAVDAGTLVA
DAQTLDIFSRAVQALQEYVTDLMAGMAEEPLRLFQPYQAVLARLGEERVHPADLWADELR
HLPALLLPSRDLVGLSRLRRKFELALLAALRLPNAAGAEHDPAVAAAYAPMEKLLHAIRA
LEREPRRTGDDLQRDLWLVLALTFGALRAGLVPADLTGKRLAARVNLLLRQYSHNNVHLP
QGLVTDALYLLAGMAYGNASVEPAGDDTLGPDIIACVQAFSIPATHAPAGALHTRHYYAL
LPAETTDALQQVGRSLETLSQQSAPVADELAAALHTLALHADALGQPALSTLASRLGEPT
DASGYDTAPTLLFLSRMLARPWALHGESGDLRSAWFAARCHELAEHARVQRAGEGTPAPI
WLSRLTDEITQRRTRGEQVRALQTQLASAETHLDAFEREGEVSGGLKEASRLFAEMQATF
VALGATEAVRATEAAQATIAALEAIGPQAAADREHYLAALASNVSGLQGFLDALSAGTEL
TGAQIDQIVIEGVLTFVERESAWRAFAFDAETGMLVRREPQVDLDAGADAAQADADVSHL
QSMLDRLLAKQPVDLADPLAAELRAALQEARDAAAIDDDPARRRRLEEALAQFDAWQAGS
PAALERMQAALAAPSAEAVVVAAPAPAASDAQSIDAELLEIFLSEAEEVLAGVRTDLQPL
HAAAQAGAGGAATGTDLDLLTQLRRAFHTLKGSGRMVGLTRYGEAAWAIEQVMNVWLAES
RVPTPDLAALLARAEADLSAWTAAIAQAPHADHPIEPLVAAADRVRHGGPFVWLEVVATP
APQAPQASAEPVAEFEPVAPAPAPEPHLHHAPEPVVTLAEVPVELEVPVEPTVAVNDAAT
LSWEDAPVLPEAETPAAAEAEAEAIAEPVAAFVAEPAGEPADEPIAEPIVEPVAEAFAVE
PASVEADAKVIPFPFEQTGAPEDASHDDGIKTIGPVYISVALYNVYLQEADALIRRLGVD
FSEWHHEGRAQPSELALRAAHTLQGSSAVVGLEPVRLIADGLEQLLLNLDSRPVVMHPGD
FRLLDQAVERMRGMLHQFAASVWPDADDALCRSLAELCERVLVRPRLQLESVSQELSGAE
AVESPVVSEDDTPEIVVPEAVPEAIAPIVPLYEAPVAGPAVAELVRQAPSDALDPALLEI
FLEEAHVALPELGQQLREWETAPQDRTVSGLLLRNLHTVKGSARMAGAMTLGQAAHEMES
AVDNGLRHNRVDDTLFRKLYVWLDRIQAHVDALGAGKLLPLDAGVRDAPDAPSAAGGDSA
AAGSMLPAVAGATSVDLAGARSPEADALEAAERQRAMVRVQARALDALINDAGEVGAARA
RLEAEVQALKSYLSELNDNVARLRAQVREIEIQAESQMESRIADAAAHSEAFDPLEFDRF
TRLQELTRMMAESVNDVATVQQNLFRGFDQASLDLETQARLTRGLQRSLMRARMVQFDTV
ADRLYRVARQAAAETGKEVRLFIKGGTVELDRSVLDRMGGPLEHMIRNAVAHGIELAEER
RTKGKSPAGELTLEVQQEGNEVVLHFVDDGAGLNLERIRARALERQLLAPDEEASEARLT
EMIFSPGFSTAQQVSELAGRGVGMDVVRAETVALGGRISLQTTPNVGTHFTIHLPLTTAI
TQVLLVRVGERVYAIPSGMIDHVQQLRPQSLAEAYNAASLELPGGAVPFHYFGALLEEAR
PVMGGRKYSPAVVVRSGNDRAAVHVDEVIGNREVVVKHIGPHLARLEGIAGATTLGNGEV
VLIYNPVVLTQRFEREAAAQGQLQADQGTTGAVAELSRNGSTDVVPGLATQPIVMVVDDS
LTVRKVTQRLLTRSGYQAVLARDGVDALRQLQEVTPDAMLVDIEMPHMDGFDLTRNVRAD
ERIGAMPIIMITSRAADKHRRYAAEIGVNVYLGKPYNEDELLRHLRNLIGARAPAANAG