Protein Info for RPSI07_RS23185 in Ralstonia solanacearum PSI07

Annotation: diguanylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00526: FolB domain
  • amino acids 15 to 127 (113 residues), 46.8 bits, E=1.6e-16
• PF02152: FolB
  • amino acids 17 to 125 (109 residues), 83.9 bits, E=6e-28

Best Hits

KEGG orthology group: K01633, dihydroneopterin aldolase [EC: 4.1.2.25] (inferred from 100% identity to rsl:RPSI07_3216)

Predicted SEED Role

"Dihydroneopterin aldolase (EC 4.1.2.25)" in subsystem Folate Biosynthesis (EC 4.1.2.25)

MetaCyc Pathways

• superpathway of tetrahydrofolate biosynthesis and salvage (11/12 steps found)
• superpathway of tetrahydrofolate biosynthesis (9/10 steps found)
• 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I (4/5 steps found)
• 6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia) (3/5 steps found)
• superpathway of chorismate metabolism (41/59 steps found)
• 6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus) (2/7 steps found)
• tetrahydromethanopterin biosynthesis (3/14 steps found)

KEGG Metabolic Maps

• Folate biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.2.25

Protein Sequence (130 amino acids)

>RPSI07_RS23185 diguanylate cyclase (Ralstonia solanacearum PSI07)
MLSLLSHPRLSHCRRLFLRNYEVQINIGVHEFEKKGEQRVLINIELYVPLEHSTPKDDKL
HEVVDYDFMRETVARRMAQGHVHLQETLCDDVVTAMLKHPHVLAARVSTEKPDVYPDCES
VGVEVFRIKD