Protein Info for RPSI07_RS11910 in Ralstonia solanacearum PSI07

Annotation: urocanate hydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 572 TIGR01228: urocanate hydratase" amino acids 20 to 570 (551 residues), 955.3 bits, see alignment E=4.8e-292 PF17391: Urocanase_N" amino acids 22 to 148 (127 residues), 207.2 bits, see alignment E=9.3e-66 PF01175: Urocanase" amino acids 151 to 365 (215 residues), 276.1 bits, see alignment E=2.9e-86 PF17392: Urocanase_C" amino acids 368 to 562 (195 residues), 310.6 bits, see alignment E=5.6e-97

Best Hits

Swiss-Prot: 77% identical to HUTU_TRIRP: Urocanate hydratase from Trifolium repens

KEGG orthology group: K01712, urocanate hydratase [EC: 4.2.1.49] (inferred from 100% identity to rsl:RPSI07_0870)

MetaCyc: 77% identical to urocanase subunit (Pseudomonas putida)
Urocanate hydratase. [EC: 4.2.1.49]

Predicted SEED Role

"Urocanate hydratase (EC 4.2.1.49)" in subsystem Histidine Degradation (EC 4.2.1.49)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.49

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (572 amino acids)

>RPSI07_RS11910 urocanate hydratase (Ralstonia solanacearum PSI07)
MNTVTDAAHLAADPRYDAAREIRAPRGTELHCKSWLTEAAYRMLQNNLDPDVAENPKHLV
VYGGIGRAARDWACFDKILETLRELNDDESLLVQSGKPVGVFKTHPDAPRVLIANSNLVP
KWANWEHFNELDRKGLFMYGQMTAGSWIYIGSQGIVQGTYETFAEAGRQHYGGKLAGRWI
LTAGLGGMGGAQPLAATLAGAVSLTIECQQSSIDFRLRTRYLDKQAKDIDDALNLIRHHC
ERGEAVSIGLLGNAAEILPALVERASAGGLKPDLVTDQTSAHDLVNGYLPAGWTVEQWRA
AQHDPSQHARLTAEAAKSCAVHVQAMLDFQAMGIPTVDYGNNIRQVAFDQGVKNAFDFPG
FVPAYIRPLFCEGKGPFRWVALSGDPEDIYKTDAKIKALFPHHAHVHRWLDMARERIAFQ
GLPARICWLGLGERHLAGLAFNEMVRKGELKAPVVIGRDHLDTGSVASPNRETEAMRDGT
DAVSDWPLLNALLNTAGGATWVSLHHGGGVGMGYSQHAGVVIVADGTESAAKRLARVLVN
DAGSGVMRHADAGYETAIACAKRNDLKLPMIG