Protein Info for RPSI07_RS08540 in Ralstonia solanacearum PSI07
Annotation: trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
MetaCyc: 76% identical to proline dehydrogenase/1-pyrroline-5-carboxylate dehydrogenase (Pseudomonas putida KT2440)
RXN-14903 [EC: 1.5.5.2]; 1.5.5.2 [EC: 1.5.5.2]; RXN-14116 [EC: 1.5.5.2, 1.2.1.88]
Predicted SEED Role
"Transcriptional repressor of PutA and PutP / Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) / Delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12)" in subsystem Arginine and Ornithine Degradation or Proline, 4-hydroxyproline uptake and utilization or Respiratory dehydrogenases 1 (EC 1.5.1.12, EC 1.5.99.8)
MetaCyc Pathways
- L-citrulline biosynthesis (8/8 steps found)
- superpathway of L-citrulline metabolism (10/12 steps found)
- ethene biosynthesis II (microbes) (4/4 steps found)
- L-Nδ-acetylornithine biosynthesis (6/7 steps found)
- L-arginine degradation I (arginase pathway) (3/3 steps found)
- L-proline degradation I (3/3 steps found)
- proline to cytochrome bo oxidase electron transfer (1/2 steps found)
- (5R)-carbapenem carboxylate biosynthesis (1/6 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.2.1.88 or 1.5.1.12 or 1.5.5.2 or 1.5.99.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (1327 amino acids)
>RPSI07_RS08540 trifunctional transcriptional regulator/proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase (Ralstonia solanacearum PSI07) MATTTLGVKLDDASRERLKRAAQSIDRTPHWLIKQAIFTYLDQVERGQLPNDASGPAADG LPSAAAVADMADADGTDTAVQPFLEFAQSVQPQSVLRAAITAAYRRPETEAIPMLLEQAR LPGALASEAKQLARDLAGKLRAQKVGTGREGLVQGLIQEFSLSSQEGVALMCLAEALLRI PDKATRDALIRDKISNGNWQSHLGQSPSLFVNAATWGLLLTGKLVATHNEAGLSKALTRI IGKRGEPLIRKGVDMAMRLMGEQFVTGETISEALANARKYEAEGFRYSYDMLGEAAMTEE DAQRYLASYEQAIRAIGQASGGRGIYEGPGISIKLSALHPRYSRAQYDRTINELYPRVKG LAMLAREYDIGINIDAEEADRLEPSLDLLERLCFAPELAGWNGIGFVVQGYQKRCPFVLD AIIDLARRSKHRLMIRLVKGAYWDSEVKRAQVDGLEGYPVYTRKVYTDVSYLACARKLLA APDAVFPQFATHNAHTLAAIYHMAGQNYYPGQYEFQCLHGMGEPLYEQVVGNKPGKLNRP CRIYAPVGTHETLLAYLVRRLLENGANTSFVNRIADESIPLDDLVADPVAVVETMHAEEG TLGLPHPKIPLPRKLYGDGRANSSGIDLANEQRLASLSSALLASTGMAWAATPTIGDAPY VSQAGSTPQPVRNPADLRDVVGHVTEATQADVDAALAAAAAAAPIWQATLPEARAALLER AADLMEGQMQSLMGLIIREAGKTLSNAISEVREAVDFLRYYAAQVRGGFSNDMHRPLGPV VCISPWNFPLAIFTGQVSAALAAGNPVLAKPAEQTPLIAAQAVRILREAGVPAGAVQLLP GRGETVGAALVKDARTKGVMFTGSTEVARILQRTLAGRLDANGAPIPLIAETGGQNAMIV DSSALAEQVVADVLSSAFDSAGQRCSALRVLCLQDDVADRVLAMLKGGMAELAMGNPDRL STDVGPVIDAEARDNIVGHIDAMRAKGRRVHQPPVPAACAHGTFVPPTVIELDGIGDLTR EIFGPVLHVVRWKRTADNTGLTRLIEQINGTGYGLTLGIHTRIDETIAHIVERAHVGNLY VNRNIVGAVVGVQPFGGEGLSGTGPKAGGPLYLLRLLSTCPQDAMRTALALTAGAGTDVE TDERRALLAPFDVLHDWAHKQAPELAALCDRLAAATAAGAVLTLPGPTGERNTYMLLPRD AVLCVAADPADWLRQVAAVLAVGSEAVVQENPAIAEVLRTLPPAVQSRVRVVASPEDAAF DAVLHHGDSDHLRALCERLARRAGPIVGVQGLPHGGQGLALERLLIERSLSVNTAAAGGN ASLMTIG