Protein Info for QEN71_RS39430 in Paraburkholderia sabiae LMG 24235

Annotation: molybdopterin-dependent oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1023 PF01315: Ald_Xan_dh_C" amino acids 49 to 159 (111 residues), 93.8 bits, see alignment E=2.5e-30 PF02738: MoCoBD_1" amino acids 176 to 423 (248 residues), 219.9 bits, see alignment E=8.9e-69 PF20256: MoCoBD_2" amino acids 452 to 765 (314 residues), 231.9 bits, see alignment E=3.4e-72 PF10604: Polyketide_cyc2" amino acids 855 to 991 (137 residues), 46.6 bits, see alignment E=1.3e-15 PF06240: COXG" amino acids 857 to 992 (136 residues), 87 bits, see alignment E=3e-28 PF03364: Polyketide_cyc" amino acids 861 to 982 (122 residues), 27.8 bits, see alignment E=7.8e-10

Best Hits

KEGG orthology group: K03520, carbon-monoxide dehydrogenase large subunit [EC: 1.2.99.2] (inferred from 93% identity to bph:Bphy_6673)

MetaCyc: 82% identical to hmfA (Cupriavidus basilensis)
2-furoyl-CoA dehydrogenase. [EC: 1.3.99.8]

Predicted SEED Role

"Carbon monoxide dehydrogenase large chain (EC 1.2.99.2)" in subsystem CO Dehydrogenase (EC 1.2.99.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.99.2

Use Curated BLAST to search for 1.2.99.2 or 1.3.99.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1023 amino acids)

>QEN71_RS39430 molybdopterin-dependent oxidoreductase (Paraburkholderia sabiae LMG 24235)
MNQRETNLAEAEAPRAAEAAALANETSEPRASKHVGRPMQRLEDPAILTGRGRYGDDIGV
KPGTLHAAVLRSPHAHAELVSIDASSASKLRGVRAVLTRDDLRPWSRPFVVGVKSPMEQW
ALAMDRVRYVGEPVAVVMAESRALAEDALDLIKVDYRILDPVTTIEQSMQDDAPVLHERV
GTNVISDRHFRYGEPEAAFESASHRVKIVTHYPRNSCAPIECGVEIAEYLSGDEGYDVTS
NFMGPFSLHAVMAMALNVPANRLRHKAPRDSGGSFGVKQAVFPYVVMMCLASRKAGAPVK
WVEDRLEHLSAATSATARLSTIEAAVDDDGRITALAYDQLEDCGGYVRAPEPATFYRMHG
CLTGAYAIPNLVVRNRVVLTNKTPTGLVRGFGGPQVYFALERLMQRIAIELKLDVLDVYR
RNFVPADAFPYRAVAGALLDSGNYQEALRRGLAEGGYDELVKRRDAARSEGRIYGIGFAA
IVEPSVSNMGYITTVMPAEARKKAGPKNGAIASATVSVDLLGGVVVTVASTPAGQGHMTV
CAQVVADVLGLEPKDIVVNVEFDTHKDAWSVASGNYSSRFAGAVAGTVHLAATRVRDKLA
RIVAKQFGCAAEDVCFEGGRVYPKVAQDRALPFGRAASNAPHWAPALLPEGEEPGLRETV
FWSPPHMDAPDENDRINTSAAYGFAFDMCAIEIDRATGHVRIDRYVTTHDAGTLLNPALA
DGQIRGAFAQGLGAALLEEFRYGADGSFQSGTLADYLMPTTCEVPDPMIVHLETPSPFTP
LGAKGLGEGNNMSTPVCIANAVADALGVDDIRLPLTPSKVMALIGIDDPEPSRPEYRDAA
TEKKAAPGGGRALTAQGTVDLPATPEAVFAVLLDPAALAKVIPGCHELEATGQNQYRADV
TVGVGMIKARFEARIGLSDIDAPHRLRLEGAGMSPLGSARGNGLVELMPTEKGTRLTYDY
EAQVSGKVAAVGGRMLEGAAKVVLRQLFESLGRVAAGGEPDATGGSAPMRFLQRLFARFR
RHA