Protein Info for QEN71_RS38780 in Paraburkholderia sabiae LMG 24235

Annotation: NAD-dependent succinate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 20 to 482 (463 residues), 588.2 bits, E=5e-181
• TIGR01780: succinate-semialdehyde dehydrogenase
  • amino acids 31 to 481 (451 residues), 708.3 bits, E=2.1e-217

Best Hits

Swiss-Prot: 66% identical to DAVD_PSEAE: Glutarate-semialdehyde dehydrogenase (davD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 69% identity to cti:RALTA_A1423)

MetaCyc: 66% identical to glutarate semialdehyde dehydrogenase (Pseudomonas aeruginosa)
Glutarate-semialdehyde dehydrogenase. [EC: 1.2.1.20]

Predicted SEED Role

"Aldehyde dehydrogenase (EC 1.2.1.3)" in subsystem Entner-Doudoroff Pathway or Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism or Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate (EC 1.2.1.3)

MetaCyc Pathways

• superpathway of glycol metabolism and degradation (7/7 steps found)
• ethanol degradation II (3/3 steps found)
• ethanol degradation IV (3/3 steps found)
• 4-aminobutanoate degradation III (2/2 steps found)
• ethylene glycol degradation (2/2 steps found)
• putrescine degradation V (2/2 steps found)
• superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (6/8 steps found)
• phytol degradation (3/4 steps found)
• ethanol degradation III (2/3 steps found)
• hypotaurine degradation (2/3 steps found)
• putrescine degradation IV (2/3 steps found)
• L-lysine degradation X (4/6 steps found)
• putrescine degradation I (1/2 steps found)
• Entner-Doudoroff pathway II (non-phosphorylative) (6/9 steps found)
• mitochondrial NADPH production (yeast) (3/5 steps found)
• octane oxidation (3/5 steps found)
• superpathway of ornithine degradation (5/8 steps found)
• D-arabinose degradation II (2/4 steps found)
• L-tryptophan degradation X (mammalian, via tryptamine) (2/4 steps found)
• fatty acid α-oxidation I (plants) (2/4 steps found)
• histamine degradation (1/3 steps found)
• 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
• superpathway of L-arginine and L-ornithine degradation (8/13 steps found)
• L-lysine degradation IV (2/5 steps found)
• dopamine degradation (2/5 steps found)
• aromatic biogenic amine degradation (bacteria) (4/8 steps found)
• putrescine degradation III (1/4 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (6/11 steps found)
• L-lysine degradation I (3/7 steps found)
• serotonin degradation (3/7 steps found)
• ceramide degradation by α-oxidation (2/7 steps found)
• sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
• L-lysine degradation III (1/6 steps found)
• alkane oxidation (1/6 steps found)
• limonene degradation IV (anaerobic) (1/7 steps found)
• noradrenaline and adrenaline degradation (4/13 steps found)
• superpathway of pentose and pentitol degradation (23/42 steps found)
• ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)
• superpathway of L-lysine degradation (12/43 steps found)

KEGG Metabolic Maps

• 1,2-Dichloroethane degradation
• 3-Chloroacrylic acid degradation
• Arginine and proline metabolism
• Ascorbate and aldarate metabolism
• Butanoate metabolism
• Fatty acid metabolism
• Glutamate metabolism
• Glycerolipid metabolism
• Glycolysis / Gluconeogenesis
• Histidine metabolism
• Limonene and pinene degradation
• Lysine degradation
• Propanoate metabolism
• Pyruvate metabolism
• Tryptophan metabolism
• Tyrosine metabolism
• Urea cycle and metabolism of amino groups
• Valine, leucine and isoleucine degradation
• beta-Alanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16, 1.2.1.3

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.20 or 1.2.1.3

Protein Sequence (488 amino acids)

>QEN71_RS38780 NAD-dependent succinate-semialdehyde dehydrogenase (Paraburkholderia sabiae LMG 24235)
MPDLKDSSLLRTQCLIGGEWRAARDGRTFDVTDPATGALIASVPSMTAVETREAIAAAEA
ALPAWRALTAKARAALLRKWHDLMLEHQDDLALLMTAEQGKPLAEAKAEIAFAASFIEWF
AEEARRVDGDVIATPANDRRLVTIRQPVGVCAAITPWNFPAAMITRKAGPALAAGCTMVL
KPASQTPFSALALAVLAERAGIPAGVLNVVTGDPQPIAEELTGNPVVRKLSFTGSTGIGA
RLMEQGARHIQKLSLELGGNAPFIVFDDADLDAAIEGALISKYRNAGQTCVCANRFYVQA
GIYEAFVDKLATRVQALRCGDGREPSTQIGPLIDGRALAKVSELVTDARAQGAKVLCGGE
ALALNDDSTPRHYAPTVLTNVTPSMRVAREEIFGPVAPVMRFTDEQDVIALANDTEFGLA
SYFYTRDMARVWRVAEALEFGMVGINTGLISTAEAPFGGVKQSGVGREGSKYGIDEYLEM
KYLCMQVA