Protein Info for QEN71_RS37110 in Paraburkholderia sabiae LMG 24235

Annotation: SDR family oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 261 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details PF00106: adh_short" amino acids 7 to 193 (187 residues), 155.3 bits, see alignment E=2.2e-49 PF08659: KR" amino acids 9 to 169 (161 residues), 47 bits, see alignment E=4.3e-16 PF13561: adh_short_C2" amino acids 14 to 258 (245 residues), 155.8 bits, see alignment E=2.2e-49

Best Hits

Swiss-Prot: 38% identical to BDHA_RHIME: D-beta-hydroxybutyrate dehydrogenase (bdhA) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K00019, 3-hydroxybutyrate dehydrogenase [EC: 1.1.1.30] (inferred from 88% identity to bph:Bphy_5791)

Predicted SEED Role

"D-beta-hydroxybutyrate dehydrogenase (EC 1.1.1.30)" in subsystem Polyhydroxybutyrate metabolism (EC 1.1.1.30)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.30

Use Curated BLAST to search for 1.1.1.30

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (261 amino acids)

>QEN71_RS37110 SDR family oxidoreductase (Paraburkholderia sabiae LMG 24235)
MMLKGKGALVTGSSNGLGLAMARALAGAGCDIVLHGLEAPAEMAHTTDELASSFDVNVAY
VQADLATPAGVDALIESARAKINTLDVLINNAVVRHFAGIESFPLEQWNNALAVNLTAAF
RAIQLTLPGMRERGWGRIFNMTSVYGARGVANRVDYVTTKTALLGLTRAVAMETLNQGIT
CNAICPGSVLTPNIDGRIHALMDERGLERDDAVREFLKGKQPTGELVDAAHVGDMVVFLC
GASASQITGAMMPIEGGWLAG