Protein Info for QEN71_RS36080 in Paraburkholderia sabiae LMG 24235

Annotation: S-methyl-5-thioribose kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01636: APH
  • amino acids 33 to 292 (260 residues), 57.2 bits, E=1.2e-19
• TIGR01767: S-methyl-5-thioribose kinase
  • amino acids 35 to 414 (380 residues), 392.8 bits, E=9.3e-122

Best Hits

KEGG orthology group: K00899, 5-methylthioribose kinase [EC: 2.7.1.100] (inferred from 44% identity to dap:Dacet_2107)

Predicted SEED Role

"5-methylthioribose kinase (EC 2.7.1.100)" in subsystem Methionine Salvage (EC 2.7.1.100)

MetaCyc Pathways

• 5'-deoxyadenosine degradation II (4/4 steps found)
• S-methyl-5'-thioadenosine degradation I (2/2 steps found)
• L-methionine salvage cycle I (bacteria and plants) (5/12 steps found)
• L-methionine salvage cycle II (plants) (4/11 steps found)

KEGG Metabolic Maps

• Methionine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.100

Protein Sequence (422 amino acids)

>QEN71_RS36080 S-methyl-5-thioribose kinase (Paraburkholderia sabiae LMG 24235)
MEFEALSSSELAAYLRGVPSVYALLNEPGELDIAEVGDGNLNYVYFVSNARTPEKSVVVK
QAPPFLRLVGKSWPLTRHRMEREVAALRRFGELCPQHVPRVYHADTELYLMVMQRLSSHA
ILRQKLMDGHVYPKLTDHLSTYLAHTLFYGSDFFLAPEVKKQAVSAAINTELCKITEELV
FTFPFEDHPSNVYSNVFPKRLLERVWRTPALRVAVAEMKWSFMNDAETLLHGDLHTGSIM
VNKDETYVIDPEFAFYGPMGFDVGAVLANLLLAYFSRDWHDRRIEAEHENYREWLLDQVT
GIWSAFEKKFQKLWREHESRRKSHFIGDDPGGNCADAYRARFMQRLLASSLGFAGCKMIR
RIVGMAKVADITSISDDTVRAAIEVKCIQFAERLLIERHAFGSIAAVVDLARDIQGREHR
AQ