Protein Info for QEN71_RS35705 in Paraburkholderia sabiae LMG 24235

Annotation: altronate dehydratase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08666: SAF
  • amino acids 15 to 85 (71 residues), 44.8 bits, E=2.3e-15
• PF04295: GD_AH_second
  • amino acids 113 to 256 (144 residues), 146.1 bits, E=1.1e-46
• PF20629: GD_AH_C
  • amino acids 266 to 506 (241 residues), 338 bits, E=4.2e-105

Best Hits

KEGG orthology group: K01685, altronate hydrolase [EC: 4.2.1.7] (inferred from 74% identity to ppw:PputW619_1702)

MetaCyc: 56% identical to D-arabinonate dehydratase (Herbaspirillum huttiense)
Arabinonate dehydratase. [EC: 4.2.1.5]

Predicted SEED Role

"Altronate dehydratase (EC 4.2.1.7)" (EC 4.2.1.7)

MetaCyc Pathways

• D-galacturonate degradation I (4/5 steps found)
• D-arabinose degradation IV (4/6 steps found)
• D-arabinose degradation III (3/6 steps found)
• superpathway of hexuronide and hexuronate degradation (5/10 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (19/31 steps found)
• superpathway of pentose and pentitol degradation (23/42 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.7

Use Curated BLAST to search for 4.2.1.5 or 4.2.1.7

Protein Sequence (509 amino acids)

>QEN71_RS35705 altronate dehydratase family protein (Paraburkholderia sabiae LMG 24235)
METTALSPLRLHAHDNVAIARSPLRAGQQLAEFEGLTVADEIPAAHKLALVPLRRGDAVR
RYGQVIGYVKKDIDPGQHVHTHNLEIGAVDKEYLFCSDAKYPSAPVDPETFMGYVRPDGR
VGTRNYIGVVSTVNCSSTVAKMVVEHFARSDCLASYPNVDGVVPITHSFGCCIDHHGEGV
NQLRRTLGGYVTHANFAGVIVVGLGCEANQMGAMFLAQGIAPTGMIVPLVIQDQGGTQKT
VDAAIKAISEMLSVANEATRERVSAAHLTVALQCGGSDGYSGITANPALGAAVDLLVAHG
GTAILSETPEIYGAEHLLTRRASTVEVGQKIVDLIRWWEDYAVREKGSIDNNPTPGNKAG
GLTTILEKSLGAVAKSGSTALTGVYRYAEPIQSRGLVFMDAPGYDPMGATGQIASGANLV
AFTTGRGSCFGSKPAPSIKLATNSAMFSRMRDDMDINCGDIMDGSSTVEEKGREIFRKML
AVASGEKSKSELLGIGNEETVPWMIGAQM