Protein Info for QEN71_RS34195 in Paraburkholderia sabiae LMG 24235

Annotation: histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 613 transmembrane" amino acids 12 to 37 (26 residues), see Phobius details amino acids 152 to 177 (26 residues), see Phobius details PF07730: HisKA_3" amino acids 400 to 467 (68 residues), 57.4 bits, see alignment E=2.6e-19 PF02518: HATPase_c" amino acids 508 to 594 (87 residues), 48.9 bits, see alignment E=1.2e-16

Best Hits

KEGG orthology group: K07673, two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC: 2.7.13.3] (inferred from 92% identity to bph:Bphy_5967)

Predicted SEED Role

"Nitrate/nitrite sensor protein (EC 2.7.3.-)" in subsystem Nitrate and nitrite ammonification (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (613 amino acids)

>QEN71_RS34195 histidine kinase (Paraburkholderia sabiae LMG 24235)
MNINQSARIHRYPLYAKVCLLLACIVALITVLYLGAFMQTRGSEGFRQTLFSLDEAMRLE
HKAASLQADSPDTARALRELADSLVRNDTLLMDWRQRGAPTPEIGGALAAASASAATERT
AKPDASVGVKPDTKLAALGALRSQVAYQSEVHAAVLGLLQACTVCLLIFGVVSLAWGTRR
TLVARPNAALQALVETGLMAPQGRDEIDRLLKLQAQLAVRLRTEQDESVRLKRIVEDYIT
FADQSLELLHHICAQLAEEEPSGRTLEALLQRLVGVLRARRIALVVTESTAQLLDIDPVV
SPNGDVPSIVRARVTNELMTLAGIHTFSRLDDGQVPPPVLAAPVRVPLASYGVLIAEGEP
ETRFELRHLYLMETIASVLAHAISNLSRDVRDRRMALFEERNAIARELHDSLAQSLSYMK
IQLARLQAVLPPELSQSDIAEIARGIREGIDSAYRQLRELLTTFRSPMHAHGLASTLEEL
AEEFGSRSEVQISIDNRVPRMRLSVNEEMHVAQIVREALTNVLRHARATTAQVQLMSDGH
TMTVSIDDDGRGISRTEGDEHHFGLSIMRERARSLGGRLEVKPAERGSRVVLTFVPSALA
GYKARATSGAGVR