Protein Info for QEN71_RS33855 in Paraburkholderia sabiae LMG 24235

Annotation: NAD(P)-dependent alcohol dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 346 transmembrane" amino acids 168 to 188 (21 residues), see Phobius details PF08240: ADH_N" amino acids 26 to 136 (111 residues), 100 bits, see alignment E=1.3e-32 PF16912: Glu_dehyd_C" amino acids 145 to 278 (134 residues), 40 bits, see alignment E=6e-14 PF00107: ADH_zinc_N" amino acids 177 to 303 (127 residues), 72.3 bits, see alignment E=7.6e-24

Best Hits

Swiss-Prot: 62% identical to XYLD_AGRFC: Putative D-xylulose reductase (Atu4318) from Agrobacterium fabrum (strain C58 / ATCC 33970)

KEGG orthology group: K05351, D-xylulose reductase [EC: 1.1.1.9] (inferred from 72% identity to vpe:Varpa_4066)

MetaCyc: 56% identical to xylitol dehydrogenase (Morganella morganii)
D-xylulose reductase. [EC: 1.1.1.9]

Predicted SEED Role

"Xylitol dehydrogenase (EC 1.1.1.9)" in subsystem Ribitol, Xylitol, Arabitol, Mannitol and Sorbitol utilization (EC 1.1.1.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.9

Use Curated BLAST to search for 1.1.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (346 amino acids)

>QEN71_RS33855 NAD(P)-dependent alcohol dehydrogenase (Paraburkholderia sabiae LMG 24235)
MDALVLEGTQRISLRPFSLPQTVGPRDVRIRIHTVGICGSDIHYYQHGRIGPFVVNEPMV
LGHEAAGTVVQVGDEVQHLKPGDRVCMEPGVPDMESRASREGYYNLDPKVRFWATPPVHG
CLAPFVVHPAAFTYKLPDNVSFAEGAIVEPLSIGLQAAKKAAIKPGDVAVVLGAGTIGMM
CVLAALAGGCSRVIVCDMVPEKLELIGGTPGVTAVNIRETPVRDVVKRVTDDWGANIVFE
ASGSEKAFDGIVDLLCPGGCLVLVGMPQHPVPLDVVALQIKEARVESVFRYANIFPRAIQ
LIASGRIDVKPFISRSFAFADGIKAFEEAASGKPTDVKVQIVLEQE