Protein Info for QEN71_RS33595 in Paraburkholderia sabiae LMG 24235

Annotation: M24 family metallopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01321: Creatinase_N
  • amino acids 27 to 158 (132 residues), 67.2 bits, E=2.2e-22
• PF00557: Peptidase_M24
  • amino acids 166 to 381 (216 residues), 108.4 bits, E=4.6e-35

Best Hits

Swiss-Prot: 72% identical to CREA_PSEPU: Creatinase from Pseudomonas putida

KEGG orthology group: K08688, creatinase [EC: 3.5.3.3] (inferred from 97% identity to bph:Bphy_6284)

MetaCyc: 64% identical to creatinase (Arthrobacter sp. TE1826)
Creatinase. [EC: 3.5.3.3]

Predicted SEED Role

"Creatinase (EC 3.5.3.3)" (EC 3.5.3.3)

MetaCyc Pathways

• creatinine degradation I (3/4 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Glycine, serine and threonine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.3.3

Protein Sequence (403 amino acids)

>QEN71_RS33595 M24 family metallopeptidase (Paraburkholderia sabiae LMG 24235)
MKLENLIRIENGEKAKHTFSDAEYANRQGKLRELMARENIDAVLFTSYHNINYYADFLYC
SFGRKYGLVVTDKKVVSISANIDGGQPWRRTVGDYNVVYTDWQRDNFFRAVQGEIDNRGR
VGVEFDQMPVEVLAKLKAALPSAEFVDISAQTMRMRMIKSAEEIELIKHGANVCDVGGAA
LAAAVHEGVPEHEVALASTQAMVREIARRFPDSELMDTWTWFQSGINTDGAHNPVTTRKV
QKGDILSLNCFSMIAGYYTALERTMFFDHCPDEHLRLWKINVEVHEAGLKLIKPGARCGD
IANELNKIYAEYGVLKYRTFGYGHSFGVLSHYYGREAGLELREDIDTVLEPNMVVSMEPM
IMLPEGQPGAGGYREHDILVIGEKGATNITGFAYGPEHNIIAA