Protein Info for QEN71_RS27865 in Paraburkholderia sabiae LMG 24235

Annotation: histidinol dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 440 PF00815: Histidinol_dh" amino acids 28 to 436 (409 residues), 557.1 bits, see alignment E=1.3e-171 TIGR00069: histidinol dehydrogenase" amino acids 37 to 435 (399 residues), 520.5 bits, see alignment E=1.7e-160

Best Hits

Swiss-Prot: 90% identical to HISX_BURP1: Histidinol dehydrogenase (hisD) from Burkholderia pseudomallei (strain 1710b)

KEGG orthology group: K00013, histidinol dehydrogenase [EC: 1.1.1.23] (inferred from 97% identity to bph:Bphy_2759)

Predicted SEED Role

"Histidinol dehydrogenase (EC 1.1.1.23)" in subsystem Histidine Biosynthesis (EC 1.1.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (440 amino acids)

>QEN71_RS27865 histidinol dehydrogenase (Paraburkholderia sabiae LMG 24235)
MSIKIRKLDSSTEDFQKSLHAVLAFEASEDEAIERSVAQILADVKARGDAAVLDYTNRFD
RLNATNVAALELPLSELEAALESLEPKRRAALEAAAARVRAYHEKQKIECGSHSWQYTES
DGTVLGQKVTPLDRAGIYVPGGKAAYPSSVLMNAIPARVAGVREIVMVVPTPDGVKNPLV
LAAALLGGVDRVFTIGGAQAVGALAYGTQTIPAVDKICGPGNAYVASAKRRVFGTVGIDM
IAGPSEILVLCDGTTDPRWVAMDLFSQAEHDELAQSILLCPDDGFIARVEDAINELLPTM
PRRDVIQASLEGRGALVKVRDMEQACAIANDIAPEHLEISALEPQQWSQQIRHAGAIFLG
RYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSSLIEVSADGAQTLGEIAAELA
YGEGLQAHARSAEYRMKNTG