Protein Info for QEN71_RS26085 in Paraburkholderia sabiae LMG 24235

Annotation: xanthine dehydrogenase small subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02963: xanthine dehydrogenase, small subunit
  • amino acids 5 to 482 (478 residues), 708.5 bits, E=1.8e-217
• PF00111: Fer2
  • amino acids 16 to 57 (42 residues), 23.9 bits, 6.6e-09
• PF01799: Fer2_2
  • amino acids 85 to 167 (83 residues), 99.8 bits, E=1.5e-32
• PF00941: FAD_binding_5
  • amino acids 209 to 370 (162 residues), 161.5 bits, E=3.6e-51
• PF03450: CO_deh_flav_C
  • amino acids 381 to 481 (101 residues), 107.3 bits, E=8e-35

Best Hits

KEGG orthology group: K13481, xanthine dehydrogenase small subunit [EC: 1.17.1.4] (inferred from 94% identity to bph:Bphy_2422)

Predicted SEED Role

"Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A (1.17.1.4)" in subsystem Purine Utilization

MetaCyc Pathways

• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• guanosine nucleotides degradation II (4/4 steps found)
• superpathway of purines degradation in plants (14/18 steps found)
• superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
• adenosine nucleotides degradation II (4/5 steps found)
• guanosine nucleotides degradation I (3/4 steps found)
• guanosine nucleotides degradation III (3/4 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• purine nucleotides degradation II (aerobic) (8/11 steps found)
• ureide biosynthesis (5/7 steps found)
• purine nucleobases degradation II (anaerobic) (16/24 steps found)
• caffeine degradation III (bacteria, via demethylation) (1/7 steps found)
• theophylline degradation (1/9 steps found)
• caffeine degradation IV (bacteria, via demethylation and oxidation) (1/10 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.17.1.4

Use Curated BLAST to search for 1.17.1.4

Protein Sequence (508 amino acids)

>QEN71_RS26085 xanthine dehydrogenase small subunit (Paraburkholderia sabiae LMG 24235)
MSQPIRFYHRNAIREITDAPVTRTVLQYLREDARCTGTKEGCAEGDCGACTVVVGERNDN
GGVSFKAVNACIQFLPTLDGKALFTVEDLRQPDGSLHPVQEAMVECHGSQCGFCTPGFVM
SMWSMYEKHGHEHACANKTVPNRADIANALTGNLCRCTGYRPIIEAAERMFQLPAPKAPV
DVKALAQKLATLERGDTFHYEHNGQQFDAPRTVAALAQIKAAAPNTRILAGSTDIGLWVT
KMMRDLGHIVYVGQIAEMQKIDVTEDWISIGAGVTVERAYAELAKQYPELTEMWQRFASL
PIRNAGTLGGNVANGSPIGDSMPGLIALGARVVLRGKDVERELPLEDLYLAYQKKDMAEH
EFVVGLKVPARNAARKNFQFRTYKISKRFDSDISAVCAAFSFIADGEAIREPRIAFGGMA
ATPKRATHAEAALADNDWHEATAQIAMLALAKDYQPLSDMRATSDYRLETAKNTLYRFWL
ETRPNNPLQKGALDVRAVLAAGAEASEA