Protein Info for QEN71_RS24345 in Paraburkholderia sabiae LMG 24235

Annotation: DUF4118 domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 951 transmembrane" amino acids 414 to 432 (19 residues), see Phobius details amino acids 437 to 455 (19 residues), see Phobius details amino acids 460 to 477 (18 residues), see Phobius details amino acids 489 to 510 (22 residues), see Phobius details PF02702: KdpD" amino acids 21 to 230 (210 residues), 330.9 bits, see alignment E=7e-103 PF13493: DUF4118" amino acids 414 to 520 (107 residues), 111 bits, see alignment E=6.1e-36 PF13492: GAF_3" amino acids 541 to 662 (122 residues), 53.8 bits, see alignment E=6.6e-18 PF00512: HisKA" amino acids 682 to 752 (71 residues), 64.1 bits, see alignment 2.4e-21 PF02518: HATPase_c" amino acids 797 to 914 (118 residues), 78.2 bits, see alignment E=1.7e-25

Best Hits

KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 94% identity to bph:Bphy_2054)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (951 amino acids)

>QEN71_RS24345 DUF4118 domain-containing protein (Paraburkholderia sabiae LMG 24235)
MPRPDPDELLDKLQREEEKRQRGKLKVFFGASAGVGKTYAMLQAAKRRKEEGIDVVVGIA
ETHGRSETAALLEGLEVLPLARIEYRNRLLAEFDLDKALERKPQLILVDELAHSNVQGAR
HAKRWQDVYELLDAGIDVYTTVNVQHLESLNDVVGQITGIRVWETVPDRVFDRADEVTLV
DLPAEELLDRMRDGKVYMPQQAERAVRNFFRKGNLIALRELALRRTADRVDAQMREYRAD
RSIERIWQARERLLVCVGPGPEAPLLVRAAARLAASLKADWIAVYVETPKLQRLSDARRE
RTLDALKLAAELGAETATLAGADAVSTLIGYARVRNVSKLVAGGSSATGFVRWLRRPFGE
RLAERASDLDLTLIRASSDETGGTTRERLADEEGRAWRDALIAARDRRSPPRSYAWAVAI
CAGVTLIASQLIDRIDLANLVMLYLLGVIFTAVRLGRGPGVMLSFLSVAAFDFFFVPPRM
SLSVSDTQYLLTFLGMLLTSLVIGHLTSSLRREASVARRREQRTGAMYAMARELAAALTT
EQIVGIGSRHVSEVFRARVAVLLPDSADQVKQKIDDPDTNIMLDGASLDVDVGQWVYDQQ
KPAGHGTDTLPAAKALYLPLRAPMRTRGVLAVAMQDERELDVPEQQRMLDAFAAQIALAL
ERVHYVDIARDALVSMESERLRNSLLSAISHDLRTPLTAIVGFSSMLAAQRDAQTDKHNE
AQGELVDAIHEEALRMTGIVTNLLDMARLQAGSLKLNRQWSLLEETVGSALRDCRRTLAR
HPVKVSLPADLPLLQLDAVLMERLFANLFENAAKYVPPDTPLTISAQCIDENDKPFVRVT
VDDTGPGLPAGMEARIFEKFTRGEKESAKPGIGLGLAICRAIAEAHGGKIGATNRIAADG
RVEGARFWFTLPIETPPPVPDVSDVSDDAAGEPEPAQRLPQQADTHPHTDS