Protein Info for QEN71_RS24065 in Paraburkholderia sabiae LMG 24235

Annotation: acyl-CoA dehydrogenase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02771: Acyl-CoA_dh_N
  • amino acids 8 to 120 (113 residues), 62.5 bits, E=7.1e-21
• PF02770: Acyl-CoA_dh_M
  • amino acids 125 to 219 (95 residues), 75 bits, E=6.4e-25
• PF00441: Acyl-CoA_dh_1
  • amino acids 231 to 395 (165 residues), 84.2 bits, E=1.7e-27

Best Hits

KEGG orthology group: K00257, [EC: 1.3.99.-] (inferred from 94% identity to bph:Bphy_1992)

MetaCyc: 58% identical to pimeloyl-CoA dehydrogenase large subunit (Rhodopseudomonas palustris)
Pimeloyl-CoA dehydrogenase. [EC: 1.3.1.62]

Predicted SEED Role

"Putative acyl-CoA dehydrogenase oxidoreductase (EC 1.3.99.3), may be related to NAD-dependent histone acetylation" (EC 1.3.99.3)

MetaCyc Pathways

• benzoyl-CoA degradation III (anaerobic) (2/9 steps found)

KEGG Metabolic Maps

• 1- and 2-Methylnaphthalene degradation
• Benzoate degradation via CoA ligation
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Brassinosteroid biosynthesis
• Caprolactam degradation
• Fatty acid metabolism
• Geraniol degradation
• Propanoate metabolism
• Valine, leucine and isoleucine degradation
• beta-Alanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.-, 1.3.99.3

Use Curated BLAST to search for 1.3.1.62 or 1.3.99.- or 1.3.99.3

Protein Sequence (398 amino acids)

>QEN71_RS24065 acyl-CoA dehydrogenase family protein (Paraburkholderia sabiae LMG 24235)
MDLNYSPADDAFRADIRAWLEANLPDALRNKVLNHKRLNRDDYASWHKLLGKRGWSVTAW
PVEFGGPGWNATQRHIWDEECADVGAPGVLPFGVSMVAPVLMKYGSEAQKRHYLPRILDG
TDWWCQGYSEPGSGSDLASLRTRAERVGDHYVVNGQKTWTTLGQHADMMFCLVRTDSGAK
KQEGISFLLIDMKTPGITVRPIITLDEDHEVNEVFFEDVKVPVENLVGDENRGWTYAKYL
LGHERTGIARVGQSKRELVFLKQLALNQKKNGKPLLLDPLFAAKVANLEIELMALEVTVQ
RVVANEAGGRGPGPEASMLKIKGTEVQQGLTELMFEAVGPLAAPFDVPFLEGERAHSIAG
DDDAAPLAAYYFNYRKTSIYGGSNEIQKNIIAQMILGL