Protein Info for QEN71_RS23505 in Paraburkholderia sabiae LMG 24235

Annotation: urocanate hydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 562 TIGR01228: urocanate hydratase" amino acids 15 to 559 (545 residues), 966.1 bits, see alignment E=2.5e-295 PF17391: Urocanase_N" amino acids 17 to 143 (127 residues), 205.8 bits, see alignment E=2.5e-65 PF01175: Urocanase" amino acids 146 to 354 (209 residues), 303.8 bits, see alignment E=9.4e-95 PF17392: Urocanase_C" amino acids 357 to 551 (195 residues), 310.5 bits, see alignment E=6e-97

Best Hits

Swiss-Prot: 84% identical to HUTU_CHRVO: Urocanate hydratase (hutU) from Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)

KEGG orthology group: K01712, urocanate hydratase [EC: 4.2.1.49] (inferred from 98% identity to bph:Bphy_1812)

MetaCyc: 72% identical to urocanase subunit (Pseudomonas putida)
Urocanate hydratase. [EC: 4.2.1.49]

Predicted SEED Role

"Urocanate hydratase (EC 4.2.1.49)" in subsystem Histidine Degradation (EC 4.2.1.49)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.2.1.49

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (562 amino acids)

>QEN71_RS23505 urocanate hydratase (Paraburkholderia sabiae LMG 24235)
MNNPKHIDPRLDPSRTIRAPRGSEKTCKTWIAEAAYRMIQNNLDPEVAEHPHALVVYGGI
GRAARNWDCYDQILASLKNLEENETLLIQSGKPVGVFRTHADAPRVLLANSNLVPHWANW
DHFHELDRKGLMMYGQMTAGSWIYIGSQGIVQGTYETFFSVANQHFNGDPKGRWILTGGL
GGMGGAQPLAATMAGFSMIAVECDETRIDFRLKTRYVDKKAKTLDEALAMIDEAKKTGNP
VSIGLLGNAADVFAELVARNITPDCVTDQTSAHDPIHGYLPQGWKIEDWRERMKTDPQSI
VTPAKQSMAKQVQAMLTLQERGAATLDYGNNIRQMALEMGVQNAFDFPGFVPAYIRPLFC
EGKGPFRWVALSGDPEDIYKTDQKVKELIPDDPHLHNWLDMARERIAFQGLPARICWVGV
KDRYRLGQAFNEMVKKGELKAPIVIGRDHLDTGSVASPNRETESMKDGSDAVSDWPLLNA
LLNTAGGASWVSLHHGGGVGMGFSQHSGVVIVADGSDAAHERLGRVLFNDPATGVMRHAD
AGYELAQSTAREAGLNLPMLGR