Protein Info for QEN71_RS22955 in Paraburkholderia sabiae LMG 24235

Annotation: acyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 832 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details transmembrane" amino acids 44 to 63 (20 residues), see Phobius details amino acids 283 to 296 (14 residues), see Phobius details amino acids 588 to 608 (21 residues), see Phobius details PF02771: Acyl-CoA_dh_N" amino acids 130 to 236 (107 residues), 68.3 bits, see alignment E=1.6e-22 PF00441: Acyl-CoA_dh_1" amino acids 363 to 503 (141 residues), 53.4 bits, see alignment E=6.6e-18 PF09317: ACDH_C" amino acids 517 to 807 (291 residues), 369.6 bits, see alignment E=2.7e-114

Best Hits

Swiss-Prot: 58% identical to FADE_YERPE: Acyl-coenzyme A dehydrogenase (fadE) from Yersinia pestis

KEGG orthology group: K06445, acyl-CoA dehydrogenase [EC: 1.3.99.-] (inferred from 94% identity to bph:Bphy_1700)

Predicted SEED Role

"Butyryl-CoA dehydrogenase (EC 1.3.99.2)" in subsystem Acetyl-CoA fermentation to Butyrate or Anaerobic respiratory reductases or Butanol Biosynthesis or Isobutyryl-CoA to Propionyl-CoA Module or Isoleucine degradation or Valine degradation (EC 1.3.99.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.-, 1.3.99.2

Use Curated BLAST to search for 1.3.99.- or 1.3.99.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (832 amino acids)

>QEN71_RS22955 acyl-CoA dehydrogenase (Paraburkholderia sabiae LMG 24235)
MTWFIVALIVVAGALVYVQARAAWWLAFLAAWVAAVSLTRTVGVTASIVLAVVLVLPALV
LTLKPLRRALLSRPMLNLFRKILPDMSPTERDAIEAGTVWWDAALFSGRPHWDTLLGYGP
AKLTPEEQAFLANECETLCDLANDWETTAIWQDLSPQAWQFVKDKGFLGMIIPKQYGGKA
FSAYAHSQVIMKLATRCSAAAVSVMVPNSLGPAELLLHYGTEAQKNHYLPRLARGDDIPC
FALTSPYAGSDAASIPDIGIVCKGTFEGRETLGFRVTWSKRYITLGPIATVLGLAFRALD
PDHLLGDDDEPGITCALIPTRHPGVNIGRRHWPLNAVFQNGPNSGNDVFIPLDWVIGGRE
QVGNGWRMLMECLAAGRAISLPSSNVGMSKIAVRGVGAYAAVRRQFRTSIGKFEGVQEAL
GRMGGNLYVMDAARRLSAQAVDLGEKPSVISAISKYHITERNREVIDDGMDVVAGKGICM
GPSNFLARAYQQVPISITVEGANILTRCLIIFGQGAIRCHPYVLKEMAATREPDRAKALR
GFDDAFFGHMSFTLSNAMRSFVNGVTGGLLIAKPRHAHAPLARYYRAATRLSTAFALLAD
VSMLVLGGDLKRRERISGRLGDVLSQLYLISATLKRFEDEGRHESDLPLVQWGVEDALYR
AQTALDGVLRNYPNRFAAGLVRLLAFPFGLPHRTPSDALGSAIAELMQTPGDTRDRLIAD
SYVPHVGVDPIGYGELAFELTPRVAHIEKRLREAVKAGKIEPIPQSLADLAEWNEAAQQR
GLIDEDERKVLDAYARYGAEVVKVDDFPADFGLLADLQRRKEALDKAMDLAA