Protein Info for QEN71_RS21915 in Paraburkholderia sabiae LMG 24235

Annotation: peptidylprolyl isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 259 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF13145: Rotamase_2" amino acids 111 to 233 (123 residues), 73.3 bits, see alignment E=4.6e-24 PF13616: Rotamase_3" amino acids 139 to 221 (83 residues), 85.6 bits, see alignment E=5.6e-28 PF00639: Rotamase" amino acids 141 to 220 (80 residues), 81 bits, see alignment E=1.6e-26

Best Hits

Swiss-Prot: 45% identical to PLP1_BORBR: Probable parvulin-type peptidyl-prolyl cis-trans isomerase (BB3803) from Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)

KEGG orthology group: K03769, peptidyl-prolyl cis-trans isomerase C [EC: 5.2.1.8] (inferred from 97% identity to bph:Bphy_1023)

Predicted SEED Role

"Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)" in subsystem Queuosine-Archaeosine Biosynthesis (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (259 amino acids)

>QEN71_RS21915 peptidylprolyl isomerase (Paraburkholderia sabiae LMG 24235)
MTLKNTRYWVLLAAFAAAPAFAQNIAVVNGTPIPKSRADALVAQLVQQGQQDSPKLQQAV
REELVNREILMQEAIREGIPSKPDVKAQVAVAQQTVVLRALIENYLKKNQPSDAEVKAKY
DELVKQIGGKEYHLHHILVENEQQAKDLIAKIKGGASFEDLAKQFSKDPGSGKNGGDLDW
SDPKAYVPEFAAAAEKLQKGQMTDEPVHTQFGWHIIRVDDVRQTPPPPFEQVKAQIAQQM
QQEKLQAFEEDLRSKAKVQ