Protein Info for QEN71_RS19700 in Paraburkholderia sabiae LMG 24235

Annotation: betaine/proline/choline family ABC transporter ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 387 TIGR01186: glycine betaine/L-proline transport ATP binding subunit" amino acids 16 to 366 (351 residues), 339.2 bits, see alignment E=1.5e-105 PF00005: ABC_tran" amino acids 23 to 168 (146 residues), 124.9 bits, see alignment E=5.8e-40 PF00571: CBS" amino acids 260 to 303 (44 residues), 24.8 bits, see alignment 3.4e-09 amino acids 321 to 366 (46 residues), 24 bits, see alignment 6.2e-09

Best Hits

Swiss-Prot: 67% identical to OSMV_SALTY: Osmoprotectant import ATP-binding protein OsmV (osmV) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K05847, osmoprotectant transport system ATP-binding protein (inferred from 88% identity to bgd:bgla_2g22490)

Predicted SEED Role

"L-proline glycine betaine ABC transport system permease protein ProV (TC 3.A.1.12.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (TC 3.A.1.12.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (387 amino acids)

>QEN71_RS19700 betaine/proline/choline family ABC transporter ATP-binding protein (Paraburkholderia sabiae LMG 24235)
MIELDQLTKTFTQKDGQKVTAVDSVSLKVEEGEICVFLGPSGCGKTTTLKMINRLIEPTS
GRVLINGNDTSGLNEVDLRRHIGYVIQQIGLFPNMTIEENITVVPRLLGWDKKRCAERAT
ELMSMVALDPKLYLKRYPRELSGGQQQRIGVIRALAADPPVLLMDEPFGAVDPINRETIQ
NEFFAMQRQLKKTVIMVSHDIDEAIKLGDRVAVFRRGKLVQYDHPDTLLAHPRDDFVGQF
VGADSTLKRLLLVKAGDAATQPETVRAETPLADAFAIMDENDSRYLTVLDGEQRALGLVS
RRAARGAQGVCGDKLTEFQASVSPDENLRIVLSKMYQFRSSWMPVLDTEGHYVGEITQDS
IADYLSSGRSRQQTGHVPVTRAVEFNT