Protein Info for QEN71_RS19280 in Paraburkholderia sabiae LMG 24235

Annotation: Na+/H+ antiporter NhaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 408 transmembrane" amino acids 23 to 47 (25 residues), see Phobius details amino acids 68 to 86 (19 residues), see Phobius details amino acids 103 to 124 (22 residues), see Phobius details amino acids 134 to 154 (21 residues), see Phobius details amino acids 160 to 184 (25 residues), see Phobius details amino acids 190 to 211 (22 residues), see Phobius details amino acids 217 to 248 (32 residues), see Phobius details amino acids 269 to 295 (27 residues), see Phobius details amino acids 302 to 327 (26 residues), see Phobius details amino acids 339 to 360 (22 residues), see Phobius details amino acids 368 to 389 (22 residues), see Phobius details PF06965: Na_H_antiport_1" amino acids 16 to 389 (374 residues), 477.1 bits, see alignment E=1.9e-147 TIGR00773: Na+/H+ antiporter NhaA" amino acids 17 to 389 (373 residues), 460.5 bits, see alignment E=2e-142

Best Hits

Swiss-Prot: 60% identical to NHAA1_PELCD: Na(+)/H(+) antiporter NhaA 1 (nhaA1) from Pelobacter carbinolicus (strain DSM 2380 / NBRC 103641 / GraBd1)

KEGG orthology group: K03313, Na+:H+ antiporter, NhaA family (inferred from 60% identity to pca:Pcar_1390)

MetaCyc: 55% identical to Na+:H+ antiporter NhaA (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-129; TRANS-RXN-292

Predicted SEED Role

"Na+/H+ antiporter NhaA type" in subsystem Na(+) H(+) antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (408 amino acids)

>QEN71_RS19280 Na+/H+ antiporter NhaA (Paraburkholderia sabiae LMG 24235)
MVIGNTLRKTNEGISNFLKLESAGGLILAATAALALICSNSPLRVAYNELLTIPVEVRVG
SLSLGKPLLLWINDGLMAIFFFLIGLEVKREVVEGELSSPAQVVLPVVAGSGGMLLPALV
FFVINRESGVAMNGWAIPTATDIAFALGILSLLGDRVPGALKIFLTAVAIADDLGAIIII
ALFYTADLSFLMLILAVVAIALLFGFNFFGVTRIAPYVIVGVILWVFVLKSGVHATLAGV
VTAFAVPLRAKDAEGHVPLHWLEQNLHPWVAFGVLPIFAFANAGVSFTGITIAALADPLP
LGIAAGLFVGKVVGVFGASAVLIGLGLSKLPAGVSWSQLAGVAALCGIGFTMSLFIGSLA
FEGQEYFTPIRLGVIAGSLLSGVTGYLLLRFVPRRATKVSLDGRAVEP