Protein Info for QEN71_RS17920 in Paraburkholderia sabiae LMG 24235

Annotation: aldolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00596: Aldolase_II
  • amino acids 15 to 193 (179 residues), 157.5 bits, E=1.8e-50

Best Hits

Swiss-Prot: 72% identical to OTNC_CUPNH: 3-oxo-tetronate 4-phosphate decarboxylase (otnC) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

KEGG orthology group: None (inferred from 97% identity to bph:Bphy_4425)

MetaCyc: 44% identical to 3-dehydro-4-phosphotetronate decarboxylase (Haemophilus influenzae Rd KW20)
RXN-18589 [EC: 1.1.1.409, 4.1.1.104]; RXN-18588 [EC: 1.1.1.409, 4.1.1.104, 1.1.1.408]

Predicted SEED Role

"Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases"

MetaCyc Pathways

• L-threonate degradation (4/4 steps found)
• D-erythronate degradation II (3/4 steps found)
• D-erythronate degradation I (1/3 steps found)
• D-threonate degradation (1/3 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.408 or 1.1.1.409 or 4.1.1.104

Protein Sequence (218 amino acids)

>QEN71_RS17920 aldolase (Paraburkholderia sabiae LMG 24235)
MTLAVHTSKEAKVREEICVTGASLYERGYTVGSAGNISARLDDGWLITPTDACLGRLDPA
EIAKVDLDGNAVSGGKPSKTLALHRGVYERNREARGIVHTHSTHLVALTLAGVWNDADVL
PPITPYYVMKVGHIPLIRYKRPGDPQVAQQIASLAESVRGVLLERLGPVVWERSVSQASY
VIEELEETARLWLMTNPRPAPLDDTALDELRTVFGARW