Protein Info for QEN71_RS17330 in Paraburkholderia sabiae LMG 24235

Annotation: heavy metal translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 840 transmembrane" amino acids 191 to 210 (20 residues), see Phobius details amino acids 216 to 237 (22 residues), see Phobius details amino acids 256 to 275 (20 residues), see Phobius details amino acids 281 to 298 (18 residues), see Phobius details amino acids 438 to 457 (20 residues), see Phobius details amino acids 465 to 491 (27 residues), see Phobius details amino acids 791 to 809 (19 residues), see Phobius details amino acids 814 to 833 (20 residues), see Phobius details TIGR00003: copper ion binding protein" amino acids 20 to 81 (62 residues), 41 bits, see alignment 4.4e-14 amino acids 102 to 163 (62 residues), 36 bits, see alignment 1.6e-12 PF00403: HMA" amino acids 21 to 80 (60 residues), 66.2 bits, see alignment 5.6e-22 amino acids 103 to 162 (60 residues), 64.3 bits, see alignment 2.2e-21 TIGR01511: copper-translocating P-type ATPase" amino acids 236 to 834 (599 residues), 573.3 bits, see alignment E=1.6e-175 TIGR01525: heavy metal translocating P-type ATPase" amino acids 254 to 833 (580 residues), 619.7 bits, see alignment E=1.4e-189 TIGR01494: HAD ATPase, P-type, family IC" amino acids 291 to 552 (262 residues), 158.5 bits, see alignment E=4.9e-50 amino acids 649 to 813 (165 residues), 126.8 bits, see alignment E=2e-40 PF00122: E1-E2_ATPase" amino acids 319 to 498 (180 residues), 194.3 bits, see alignment E=2.8e-61 PF00702: Hydrolase" amino acids 514 to 745 (232 residues), 114.3 bits, see alignment E=1.9e-36

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 90% identity to bph:Bphy_4316)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (840 amino acids)

>QEN71_RS17330 heavy metal translocating P-type ATPase (Paraburkholderia sabiae LMG 24235)
MTELATPRPADTSRPAAFPELDIQGMTCASCALRVEKALAKVPGVARASVNLATEKATVD
ADASVAVDTLINAVRKAGYEAQPVLGTTPPASVAGSSADLAELAIGGMTCAACSGRVEKA
LARIPGVTSATVNLATEKATVTTNGAVGVDQLIAAVTKAGYQATPLSADDATPAATEDKD
AAARRAVRRELGAVVICALLTLPLIVPMFAEPLGLHAMLPATLQLALATVVQFVFGARFY
RAAWKAVRAWSGNMDLLVALGTSAAYGVSVYQMALHPGDTMHLYFEASAVVITLVRFGKW
LEARAKRQTTDAIRALNALRPDRARIVVGTEEHEVPLAQVRVGMTVAVRPGERVPVDGTV
LQGRTHIDESLITGESLPVPKQPDDRVTAGSINGEGAITVTTTAIGAETTLARIIRLVET
AQAEKAPIQRLVDRVSEIFVPAILAIALVTVIGWLVTGHSAETAILNAVAVLVIACPCAL
GLATPTAIMAGAGVAARHGVLIKDAQALEIAHQVRVVAFDKTGTLTVGQPSVTAFEAVQG
IDRTHALALAAAVQRHSEHPLAKAVVKAFDTRSSGSSLPVAGDARAVAGRGVEADIDGET
FAIGSSRWLAELNVAPPPALADRARELEAQGNTVSWLIKRGKAEAKAESKTQALALIAFG
DTLKPGARAAIERLSRMGVKSALVTGDNEGSAKSVAAALGIDEVHAQVLPSDKARVVHDL
KIRTSSVVAMAGDGINDAPALAAADIGIAMATGTDVAMHAAGITLMRGDPTLVADAIDIS
RRTWSKIRQNLFWAFVYNLIGIPLAAFGLLNPMIAGAAMAFSSVSVVTNALLLRTWRSSH