Protein Info for QEN71_RS17280 in Paraburkholderia sabiae LMG 24235
Annotation: AGE family epimerase/isomerase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01809, mannose-6-phosphate isomerase [EC: 5.3.1.8] (inferred from 90% identity to bph:Bphy_4306)Predicted SEED Role
"Mannose-6-phosphate isomerase (EC 5.3.1.8)" in subsystem Alginate metabolism or Mannose Metabolism (EC 5.3.1.8)
MetaCyc Pathways
- colanic acid building blocks biosynthesis (11/11 steps found)
- GDP-mannose biosynthesis (4/4 steps found)
- β-1,4-D-mannosyl-N-acetyl-D-glucosamine degradation (2/3 steps found)
- D-mannose degradation I (1/2 steps found)
- D-mannose degradation II (1/2 steps found)
- mannitol degradation II (2/4 steps found)
- superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis (9/14 steps found)
- mannitol biosynthesis (1/3 steps found)
- 1,5-anhydrofructose degradation (2/5 steps found)
- β-(1,4)-mannan degradation (2/7 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 5.3.1.8
Use Curated BLAST to search for 5.3.1.8
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (364 amino acids)
>QEN71_RS17280 AGE family epimerase/isomerase (Paraburkholderia sabiae LMG 24235) MNATATTPELAAALRDHFGRVILPIWRGPGFNAALGLPYEAVAADGRTPMPVTRYRAMAC ARQMFVFALAGEIQHAQRLFESLNRLFRDSKHGGWFYSVDAHGVPLDTTKDLYTHAFVVF ACAEYGARSGDRDALSIVHEASSLIEDRFAADNGLLHAALAADFSTTGGMPLQNPLMHLT EAWLAARAATGDAAFDAALAKLGGAIERTFVHESTGCIAELPMGSADNRLEPGHQFEWFW LVQQAGDVLAGSGLRDALARAFMFAHERGIDAATGGVHAALDEAGNIKDSTQRIWAQTEY LRALAVHDDAAIRAVLPQQIERFRPRFLNAQGWIECKTQTGDVAREDMPSTTPYHLATAY AALP