Protein Info for QEN71_RS17165 in Paraburkholderia sabiae LMG 24235

Annotation: NAD-dependent succinate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 15 to 471 (457 residues), 589.3 bits, E=2.4e-181
• TIGR01780: succinate-semialdehyde dehydrogenase
  • amino acids 24 to 470 (447 residues), 717 bits, E=4.8e-220

Best Hits

Swiss-Prot: 63% identical to DAVD_PSEAE: Glutarate-semialdehyde dehydrogenase (davD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 90% identity to bpy:Bphyt_6931)

MetaCyc: 63% identical to glutarate semialdehyde dehydrogenase (Pseudomonas aeruginosa)
Glutarate-semialdehyde dehydrogenase. [EC: 1.2.1.20]

Predicted SEED Role

"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)

MetaCyc Pathways

• 4-aminobutanoate degradation III (2/2 steps found)
• L-lysine degradation X (4/6 steps found)
• L-lactaldehyde degradation (aerobic) (1/2 steps found)
• lactate biosynthesis (archaea) (3/5 steps found)
• L-rhamnose degradation II (5/8 steps found)
• methylglyoxal degradation IV (1/3 steps found)
• methylglyoxal degradation V (1/3 steps found)
• L-lysine degradation IV (2/5 steps found)
• superpathway of methylglyoxal degradation (4/8 steps found)
• L-lysine degradation I (3/7 steps found)
• L-lysine degradation III (1/6 steps found)
• superpathway of fucose and rhamnose degradation (5/12 steps found)
• superpathway of L-lysine degradation (12/43 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Lysine degradation
• Pyruvate metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16, 1.2.1.22

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.20 or 1.2.1.22

Protein Sequence (479 amino acids)

>QEN71_RS17165 NAD-dependent succinate-semialdehyde dehydrogenase (Paraburkholderia sabiae LMG 24235)
MSEFLRTGHYINGEWYESANTYAVRNPATGDVIANVAKGGAQETQQAIDAAERAFPAWRA
LTAKERGARVKRWGELMLEHRDALAELLTREQGKPLAEAKGEVGYAASFFEWFAEEAKRS
YGDVIPSPKPDSKIIVTREPVGVVAAITPWNFPLAMITRKAGPALAAGCTMVLKPSEETP
LSAFALAVLAERAGIPAGVFNIVSGDAVAIGGVLTESPVVRKLSFTGSTRVGKLLAKQSA
DTLKKLSLELGGNAPFIVFDDADVDAAVQGAMASKFRNTGQTCVCVNRFYVQDGIYDAFT
KALTEAVRKMRVGDALKGEVEQGPLINEAALMKVEAHVADALQHGARALTGGKRHSLGGT
FYEPTVLVDASQPMLIAEEETFGPVAACFRFKTEDEAIKAANDTPFGLSAYFYTRDLGRA
WRVAEALESGMVGINEGIISTEVAPFGGVKQSGLGREGSKYGMDEYVELKYMMMGGLGR