Protein Info for QEN71_RS16080 in Paraburkholderia sabiae LMG 24235

Annotation: AMP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00501: AMP-binding
  • amino acids 50 to 405 (356 residues), 248.7 bits, E=8.8e-78
• PF13193: AMP-binding_C
  • amino acids 459 to 537 (79 residues), 88.4 bits, E=5e-29

Best Hits

KEGG orthology group: K08295, 2-aminobenzoate-CoA ligase [EC: 6.2.1.32] (inferred from 92% identity to bph:Bphy_4075)

Predicted SEED Role

"Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases"

MetaCyc Pathways

• anthranilate degradation II (aerobic) (2/2 steps found)
• anthranilate degradation III (anaerobic) (1/2 steps found)
• 4-hydroxy-2(1H)-quinolone biosynthesis (3/5 steps found)
• aurachin RE biosynthesis (1/5 steps found)
• superpathway of quinolone and alkylquinolone biosynthesis (3/10 steps found)
• 2-heptyl-3-hydroxy-4(1H)-quinolone biosynthesis (1/8 steps found)
• aurachin A, B, C and D biosynthesis (3/11 steps found)
• anaerobic aromatic compound degradation (Thauera aromatica) (5/27 steps found)

KEGG Metabolic Maps

• Acridone alkaloid biosynthesis
• Benzoate degradation via CoA ligation
• Biosynthesis of alkaloids derived from shikimate pathway
• Carbazole degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.2.1.32

Protein Sequence (546 amino acids)

>QEN71_RS16080 AMP-binding protein (Paraburkholderia sabiae LMG 24235)
MEPSAHVDTFARDHLPPQDQWPVFLLDNPDVTYPARFNCATELLDRAVENGYGDRPAIWS
DVDGKPHSTTYGELLAMVNRSAHVLIDEMGLQPGNRVLLRGPNTLQMAVAFLAALKAGLV
VVPTMPLLRAKELKQIIDKAQISAALCDTRLMEELSRCSTAGDEFFCPSLKQTTIFHDDD
AAGSLETLAASKPAEFKACDTAADDVCLIAFTSGTTGAPKGCMHFHRDVIAMCDLFPRHI
LKATPDDIFCGTPPLAFTFGLGGLLCFPLRAGASTVLIEKQTPETLLQNVERFRTTVMFT
APTFYRQMAPLIPRFDISSLKKTVSAGEALPDSTRALWREASGIEMIDGIGGTELIHIFI
SSAGHDVRPHAIGKAVPGYIVQAVDDDMRPVPAGTLGKLAVRGPTGCRYLADDRQRKFVR
DGWNLPGDSVYIDEDGYVFYQARADDMIVSAGYNISGPEVESVLMQHAAVAECGVIGVPD
ETRGQIVKAFVVLNKGFSADEKLVAELQEFVKNTVAPYKYPRVVAFIDALPRTETGKLKR
FALRAM