Protein Info for QEN71_RS15365 in Paraburkholderia sabiae LMG 24235

Annotation: NADH-quinone oxidoreductase subunit M

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 511 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details amino acids 35 to 55 (21 residues), see Phobius details amino acids 85 to 105 (21 residues), see Phobius details amino acids 112 to 130 (19 residues), see Phobius details amino acids 136 to 156 (21 residues), see Phobius details amino acids 168 to 188 (21 residues), see Phobius details amino acids 208 to 229 (22 residues), see Phobius details amino acids 243 to 265 (23 residues), see Phobius details amino acids 271 to 293 (23 residues), see Phobius details amino acids 300 to 319 (20 residues), see Phobius details amino acids 331 to 349 (19 residues), see Phobius details amino acids 370 to 391 (22 residues), see Phobius details amino acids 403 to 425 (23 residues), see Phobius details amino acids 446 to 465 (20 residues), see Phobius details TIGR01972: proton-translocating NADH-quinone oxidoreductase, chain M" amino acids 7 to 484 (478 residues), 558.6 bits, see alignment E=5.9e-172 PF00361: Proton_antipo_M" amino acids 134 to 414 (281 residues), 223.9 bits, see alignment E=1.4e-70

Best Hits

Swiss-Prot: 46% identical to NQO13_PARDE: NADH-quinone oxidoreductase chain 13 (nqo13) from Paracoccus denitrificans

KEGG orthology group: K00342, NADH dehydrogenase I subunit M [EC: 1.6.5.3] (inferred from 98% identity to bph:Bphy_3973)

Predicted SEED Role

"NADH-ubiquinone oxidoreductase chain M (EC 1.6.5.3)" in subsystem Respiratory Complex I (EC 1.6.5.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.6.5.3

Use Curated BLAST to search for 1.6.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (511 amino acids)

>QEN71_RS15365 NADH-quinone oxidoreductase subunit M (Paraburkholderia sabiae LMG 24235)
MHLPSVLDLLIWVPIVAGIVVLLGGSDNARSRTRWLALIGAAVSILPVIPLVSGFDSSLS
TMQFEQQLAWLPEFGISYHLGVDGISLWFTVLTSVTTLIIVIASWESISSRVAQYYGAFL
LLSGCMQGVFTSLDGMLFFVFFEASLIPLYLLIGTWGEQRRVYAAVRFFFFSLVGSLAML
AALIYLWAHAHTFDIATWRTLKLDFTPQLMVFIGFLAAFSVKVPMWPVHTWLPDVHSDGP
TGAAVLLGMLKMGGYGLLRFALPIVPDACHFFAPAMIALSLVAVIYGSLLALAQTDMRKL
LAYSAVAHMGLVTLGLFTFDRMGTEGAVVQMLSYGIVSGAMLLCTGMLFDRTKNGSIDAY
GGVANSMPKLATFAMLFSMANVGLPGTSGFVGEFLVLMGAIRFNFWVGATAALTLILSAA
YTLWMYKRVMFGAIKNTRVSSLRDLGRREFVLLGAMAVLVLAIGVRPKTFTDAIGPAAEN
LVAQAQGSALPTDTGVASNNRATASSTRLPG