Protein Info for QEN71_RS15280 in Paraburkholderia sabiae LMG 24235

Annotation: sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 466 transmembrane" amino acids 6 to 25 (20 residues), see Phobius details amino acids 172 to 194 (23 residues), see Phobius details PF08521: 2CSK_N" amino acids 18 to 163 (146 residues), 120 bits, see alignment E=1.3e-38 PF00512: HisKA" amino acids 241 to 305 (65 residues), 43.8 bits, see alignment E=3.2e-15 PF02518: HATPase_c" amino acids 355 to 458 (104 residues), 89.1 bits, see alignment E=4e-29

Best Hits

KEGG orthology group: K07649, two-component system, OmpR family, sensor histidine kinase TctE [EC: 2.7.13.3] (inferred from 94% identity to bph:Bphy_3957)

Predicted SEED Role

"Signal transduction histidine kinase"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (466 amino acids)

>QEN71_RS15280 sensor histidine kinase (Paraburkholderia sabiae LMG 24235)
MTGSLRIRLLWWLLVPLAIYVFVTGKAEYDNARRTADLVQDNTLLSSARMIAGEVEWADG
MLRVDIPPAALEIFASPYGDQVFYNVSVDDDRLLAGVPDFPLSAKASASATHDSPTYYDA
DLHGRSIRAIGYVRRMYDNGATRRVLVSVGKTQASRDAMVRELWRPQLVRQLEMMLLAVA
LACIGLTFELRPLLKVKSEVMDRDPMQLEPLRVDRLHTELRPIVDAINQCIARLGVQVAV
QRRFIADAAHQLRTPLTLLDTQLQYARQHRELEPSLGEALAAMQRSNRSMVGLTNKLLLL
AQAEAADYTQLANQPVDLASIAKDVIEDLALFAQKRDIDLGAELEASAWMTGHEGLLSAL
VSNLAENAIRYTQRGGHVTVAVRGDAARVVLSVTDDGPGIPAEARSRVFEPFYRASADTE
GTGLGLAIAREIVQAHRGEIALVTGEGEARGLTVKVTFVAASTDAA