Protein Info for QEN71_RS15270 in Paraburkholderia sabiae LMG 24235

Annotation: EAL domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 645 transmembrane" amino acids 32 to 51 (20 residues), see Phobius details amino acids 57 to 78 (22 residues), see Phobius details amino acids 99 to 119 (21 residues), see Phobius details amino acids 125 to 144 (20 residues), see Phobius details amino acids 151 to 168 (18 residues), see Phobius details amino acids 174 to 196 (23 residues), see Phobius details TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 226 to 385 (160 residues), 101.9 bits, see alignment E=1.5e-33 PF00990: GGDEF" amino acids 227 to 382 (156 residues), 123.8 bits, see alignment E=5.9e-40 PF00563: EAL" amino acids 404 to 635 (232 residues), 239.6 bits, see alignment E=3.3e-75

Best Hits

KEGG orthology group: None (inferred from 92% identity to bph:Bphy_3955)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (645 amino acids)

>QEN71_RS15270 EAL domain-containing protein (Paraburkholderia sabiae LMG 24235)
MIRPQDPASFRTDPAEQAALSRSQFDAFSRQLPLLYVILVINSIAVAVTHADIAPAWLAI
WLPAAMCSACAVRLVVWVRRRQHLASLTDEEVASRLKTTVWLIALLGVIFTGWGLLLFPY
GDPYARAHVAFYMSITVIGCIFCLMHMRKAALLLTAVVIVPFSLFFSLTHNAVLVAIAIN
MLLVAVAMIFVLLTYYRDFATLVASKHALQAKQSELQRLSDENSRLANLDNLTGLPNRRR
FLADLDALFQTSEAEGRRFAVGVIDLDGFKQVNDLYGHGAGDRVLEEVGRRLLEMSGPRI
RLARLGGDEFGLLVTDVREPQDLRAIGAAICETLRAPYAWPGATARLSGSLGFAIYPDAG
LSPAQLFERADYALYFAKEHRRGGTTIFSSEHEKQIRELGQIEQALRQADLEREMTLHFQ
PIVDVVRERIVSYEALARWDSPTLGAVPPSLFIKVAERSDFIHTVTVALLRKVLATMREC
DPAVRVAFNLSARDIGSADAVANITAIVRESGVEPKRLTFEVTETAVIQDFEQASASLEA
FKRLGAHISLDDFGTGYSSLTCIHRLPLDKIKIDRGFLDRIDDDPAAQDIVRSIVELCRS
LELTCVAEGVQTEAQANVLRGLGCTAMQGFYFGKPRLFDEQPLTA