Protein Info for QEN71_RS14705 in Paraburkholderia sabiae LMG 24235

Annotation: cyclodeaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02992: ectoine utilization protein EutC
  • amino acids 4 to 327 (324 residues), 513.4 bits, E=1.2e-158
• PF02423: OCD_Mu_crystall
  • amino acids 19 to 319 (301 residues), 197.3 bits, E=3.2e-62
• PF01488: Shikimate_DH
  • amino acids 124 to 220 (97 residues), 46.5 bits, E=4.1e-16

Best Hits

Swiss-Prot: 61% identical to Y0419_RHIME: Putative dehydrogenase RB0419 (eutC) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K01750, ornithine cyclodeaminase [EC: 4.3.1.12] (inferred from 91% identity to bph:Bphy_3863)

Predicted SEED Role

"Ornithine cyclodeaminase (EC 4.3.1.12)" in subsystem Arginine and Ornithine Degradation (EC 4.3.1.12)

MetaCyc Pathways

• L-arginine degradation VII (arginase 3 pathway) (2/2 steps found)
• L-ornithine degradation I (L-proline biosynthesis) (1/1 steps found)
• L-proline biosynthesis II (from arginine) (1/2 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.3.1.12

Use Curated BLAST to search for 4.3.1.12

Protein Sequence (333 amino acids)

>QEN71_RS14705 cyclodeaminase (Paraburkholderia sabiae LMG 24235)
MTAITLLGEAQLRELVPLDLPAIDQVEAAFLSLATEAVAMPPILRLDLPEHRGEVDVKTA
YLPRFDSFAIKVSPGFFDNPKLGLPSLNGLMLVLSAKTGLTEAVLLDNGYLTAVRTAAAG
AVAARWLAKQHAPKVAVIGAGEQARLQLRALSMVRKVEHMTVWARNRVNAEQFAADMSAQ
LRITCEVARDVHHALAEADIAITTTPSTEPLIQAADLHPGLHITAMGSDAEHKNEIAPQA
LAATRYVCDRVTQTRVLGELHHAIEAGLVDAHAPHAELGQIIAGQAKGRTSDSDITLCDL
TGTGAQDTAIATLAVARARAADAGTIFRNDMKR