Protein Info for QEN71_RS13875 in Paraburkholderia sabiae LMG 24235

Annotation: NAD(P)/FAD-dependent oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 351 PF07992: Pyr_redox_2" amino acids 16 to 301 (286 residues), 82.5 bits, see alignment E=9.2e-27 PF13738: Pyr_redox_3" amino acids 71 to 295 (225 residues), 61.9 bits, see alignment E=1.5e-20 PF13434: Lys_Orn_oxgnase" amino acids 90 to 203 (114 residues), 22.5 bits, see alignment E=1.4e-08 PF00070: Pyr_redox" amino acids 164 to 206 (43 residues), 23.4 bits, see alignment 1.8e-08

Best Hits

Swiss-Prot: 87% identical to FENR_PARP8: Ferredoxin--NADP reductase (Bphy_3740) from Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)

KEGG orthology group: K00384, thioredoxin reductase (NADPH) [EC: 1.8.1.9] (inferred from 87% identity to bph:Bphy_3740)

Predicted SEED Role

"Thioredoxin reductase (EC 1.8.1.9)" in subsystem Glycine reductase, sarcosine reductase and betaine reductase or Thioredoxin-disulfide reductase or Wyeosine-MimG Biosynthesis (EC 1.8.1.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.9

Use Curated BLAST to search for 1.8.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (351 amino acids)

>QEN71_RS13875 NAD(P)/FAD-dependent oxidoreductase (Paraburkholderia sabiae LMG 24235)
MTTASNTQPASPISTDVLIIGAGPVGLFAAFEAGVIGLSSVIVDNIERVGGQCIELYPDK
PIYDIPAIPSCTARELVDRLLEQCRPFEPPLHLGHRVETVERQDSGRWLARTDKGLTFDA
ASILIAAGNGSFVPQRLQLDDAAPLEGRHVHYSVRSLDDFAGKKVVVAGGGDSALDWTLA
LLSVAERVTLVHRRNGFSATDSSVANMRRAVEAGEMDFAVGTITNLNAPGGRLESIDIRQ
AEGSVQHAADHLLVLFGLVADLGPIANWGIEVQGGRITVDTSNYESSCPGIFAAGDIAGY
PNKQKLILSGFHEASLALRKAYSYAFPEKKRVHIHSSYDAKLAERVAASHA