Protein Info for QEN71_RS11690 in Paraburkholderia sabiae LMG 24235
Annotation: NADP-dependent succinate-semialdehyde dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 70% identical to DAVD_PSEAE: Glutarate-semialdehyde dehydrogenase (davD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 90% identity to bvi:Bcep1808_3590)MetaCyc: 70% identical to glutarate semialdehyde dehydrogenase (Pseudomonas aeruginosa)
Glutarate-semialdehyde dehydrogenase. [EC: 1.2.1.20]
Predicted SEED Role
"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)
MetaCyc Pathways
- 4-aminobutanoate degradation III (2/2 steps found)
- L-lysine degradation X (4/6 steps found)
- L-lactaldehyde degradation (aerobic) (1/2 steps found)
- lactate biosynthesis (archaea) (3/5 steps found)
- L-rhamnose degradation II (5/8 steps found)
- methylglyoxal degradation IV (1/3 steps found)
- methylglyoxal degradation V (1/3 steps found)
- L-lysine degradation IV (2/5 steps found)
- superpathway of methylglyoxal degradation (4/8 steps found)
- L-lysine degradation I (3/7 steps found)
- L-lysine degradation III (1/6 steps found)
- superpathway of fucose and rhamnose degradation (5/12 steps found)
- superpathway of L-lysine degradation (12/43 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.2.1.16, 1.2.1.22
Use Curated BLAST to search for 1.2.1.16 or 1.2.1.20 or 1.2.1.22
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (486 amino acids)
>QEN71_RS11690 NADP-dependent succinate-semialdehyde dehydrogenase (Paraburkholderia sabiae LMG 24235) MELGTRLKDPLLLRQQAYVNGEWQNALSAESFEVNDPATGEIVGNVPLMGAPETRQAIDA ANAAWPAWRKKTAKERGAILRKWHDLMMENADDLALILSTEQGKSLAEARGEIGYAASFF EWFAEEGKRVYGDTIPTPASDKRIVVVKEPIGVCAAITPWNFPAAMITRKVGPALAAGCT IVVKPAEATPFSALALAVLAERAGVPAGVFSVVTGDPKAIGGELTSNPVVRKLSFTGSTQ VGRVLMSQCAATVKKVSLELGGNAPFIVFDDADIDAAVQGAIASKYRNSGQTCVCTNRFY VHDAVYDQFAEKLAAAVDRLKVGRGTEPDVAQGPLINEAAVQKVEAHIADALAKGASVVT GGKRHALGHGFFEPTVLRDVTPAMKVAKDETFGPLAPLFRFSSDDEVIRFANDTEFGLAA YFYSRDFARVWKVAEALEYGMVGVNTGLISNEVAPFGGVKQSGMGREGSHYGIDDYVVIK YLCMAV