Protein Info for QEN71_RS10975 in Paraburkholderia sabiae LMG 24235
Annotation: aspartate aminotransferase family protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 46% identical to YGD3_SCHPO: Uncharacterized aminotransferase C1771.03c (SPBC1773.03c) from Schizosaccharomyces pombe (strain 972 / ATCC 24843)
KEGG orthology group: K00837, [EC: 2.6.1.-] (inferred from 96% identity to bph:Bphy_5220)MetaCyc: 32% identical to lysine-8-amino-7-oxononanoate aminotransferase (Bacillus subtilis)
RXN-14930 [EC: 2.6.1.105]
Predicted SEED Role
"Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62)" in subsystem Biotin biosynthesis (EC 2.6.1.62)
MetaCyc Pathways
- biotin biosynthesis I (13/15 steps found)
- biotin biosynthesis from 8-amino-7-oxononanoate I (4/4 steps found)
- biotin biosynthesis from 8-amino-7-oxononanoate II (4/4 steps found)
- biotin biosynthesis II (5/6 steps found)
KEGG Metabolic Maps
- Aminophosphonate metabolism
- Arginine and proline metabolism
- Biotin metabolism
- Caprolactam degradation
- Lysine biosynthesis
- Lysine degradation
- Methionine metabolism
- Nucleotide sugars metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.6.1.-, 2.6.1.62
Use Curated BLAST to search for 2.6.1.- or 2.6.1.105 or 2.6.1.62
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (445 amino acids)
>QEN71_RS10975 aspartate aminotransferase family protein (Paraburkholderia sabiae LMG 24235) MTTVFHRMPKQTLPVAVKGEGIEIVDSTGKRYIDASGGAAVSCLGHSNQRVIDAIKRQAQ ALPYAHTSFFTTEPAEELASYLTERAPQGLGHVYFVSGGSEAIEAALKLARQYFVELGQP QRRHIIARRQSYHGNTLGALAIGGNAWRREPFLPLLIDAHHVSPCYAYREQRADETEEQF AQRLADELEQKILELGSDTVAAFVAETVVGATAGAVPPVREYFRKIRAVCDRYGVLLILD EIMSGMGRTGHLYACEEDGVTPDLLTIAKGLGAGYQPIGATLVSDKIYQAITGGTGFFQH GHTYIGHATACAAALEVQRVIADEHLLDNVKARGEQLRSLLREHYAQHPSIGDVRGRGLF VGVELVKDRATKTPFDAKLKLHAAIKREAFQRGLMVYPMGGTVDGKVGDHVLLAPPFICT ASDIEQIVSRLTDAIEGALAASGAA