Protein Info for QEN71_RS05400 in Paraburkholderia sabiae LMG 24235

Annotation: NCS1 family nucleobase:cation symporter-1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 501 transmembrane" amino acids 36 to 57 (22 residues), see Phobius details amino acids 67 to 88 (22 residues), see Phobius details amino acids 117 to 141 (25 residues), see Phobius details amino acids 159 to 179 (21 residues), see Phobius details amino acids 191 to 208 (18 residues), see Phobius details amino acids 233 to 255 (23 residues), see Phobius details amino acids 276 to 300 (25 residues), see Phobius details amino acids 316 to 339 (24 residues), see Phobius details amino acids 355 to 375 (21 residues), see Phobius details amino acids 382 to 407 (26 residues), see Phobius details amino acids 428 to 448 (21 residues), see Phobius details amino acids 468 to 487 (20 residues), see Phobius details TIGR00800: NCS1 nucleoside transporter family" amino acids 21 to 450 (430 residues), 378 bits, see alignment E=3e-117 PF02133: Transp_cyt_pur" amino acids 29 to 476 (448 residues), 387.8 bits, see alignment E=3.4e-120

Best Hits

KEGG orthology group: K03457, nucleobase:cation symporter-1, NCS1 family (inferred from 96% identity to bph:Bphy_1533)

Predicted SEED Role

"Possible pyrimidine permease in reductive pathway" in subsystem Pyrimidine utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (501 amino acids)

>QEN71_RS05400 NCS1 family nucleobase:cation symporter-1 (Paraburkholderia sabiae LMG 24235)
MKQTAQSADASQVAGGSSLYNDDLAPTGPAQRTWKWYHFAALWVGMVMNIASYMLAAGLT
EEGMSPWQAVLTVLLGNVIVLVPMLLIGHAGAKHGIPYAVLVRSSFGTQGAKLPAMLRAI
VACGWYGIQTWLGGSAIYTLLNILTGNALHGAALPFLDISIGQLACFLAFWALQIYFIVH
GTDSIRWLESWSAPIKVVMCIALVWWATSKAGGVGSMLSAPSQFAPGGKKEGLFWLTFWP
GLTAMVGFWATLALNIPDFTRFARTQRDQIVGQSIGLPVPMALLSVISVVVTSATVVIYG
KAIWDPIDLTSRMTGIGVGVALIILTLDTMCCNLAANLVGPAYDFSSLWPKGISYRTGGL
ITATIAIVMMPWKILATTQGYIFTWLVGYSALLGPVAGILMVDYFFIRGTRLDQRELFDE
NGEYSYTGGWNMAAVVALVIGVLPNLPGFLHTAFPASFPNVPAIFNTLYTYAWFVGLALA
SIVYGAWMKMRRSPGASMASA